Naslov
Influence of Insolation on Osteoporosis Progression in Androgen Deprived Nonmetastatic Prostate Cancer Patients

Autori
Španjol, Josip ; Maričić, Antun ; Valenčić, Maksim ; Oguić, Romano ; Krpina, Kristian ; Protić, Alen ; Ivančić, Aldo ; Bobinac, Mirna ; Fučkar, Dora ; Vojniković, Božidar

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), Suppl. 2; 79-81

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Prostate Cancer; Androgen Depivation; Osteophorosis

Sažetak
Prostate cancer is a major public health problem in all the developed countries. Increasing numbers of men with nonmetastatic prostate cancer are receiving long-term androgen deprivation therapy (ADT). ADT is associated the loss of bone mineral density and a increased risk of bone fractures. The standard recommendations for male bone health include above all optimizing calcium and vitamin D intake, and exercise. Vitamin D-3 is an essential factor in the maintenance of bone health and calcium homeostasis. The main supply of vitamin D-3 is obtained through photosynthesis in the skin. The aim of this study was to investigate the influence of insolation on osteoporosis progression in androgen deprived nonmetastatic prostate cancer patients. We divided our androgen deprived prostate cancer patients in 2 groups. The first group (A) consists of 224 patients with insolation rate less then 3h per week. The second group (B) consists of 174 patients with insolation rate greater then I Oh per week. With a questionnaire we determined, that patients from both groups were 70 to 80 years old, body mass index was 25-30 kg/m(2) , androgen deprivation was 4-6 years and received no vitamin D supplements. In the group A 21.86% suffered pathologic fractures do to osteoporosis. In the group B 10.92% patients suffered from osteoporotic bone fractures. The risk for pathological bone fractures is significantly greater in the group A. In conclusion higher insolation in androgen deprived nonmetastatic prostate cancer patients significantly decreases the osteoporosis progression and the risk of pathologic bone fractures.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA