Naslov
The significance of human papillomavirus DNA types in men with genital warts

Autori
Skerlev, Mihael ; Lipozenčić, Jasna ; Grce, Magdalena ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Dermatovenerologica Croatica 7 / - Zagreb : Hrvatsko dermatološko društvo, 1999, 188-188

Skup
5th Alpe-Adria-Danube sexually transmitted diseases workshop with annual meeting of Croatian dermatological society

Mjesto i datum
Opatija, Hrvatska, 29.10.1999. - 31.10.1999

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
human papillomavirus; male population

Sažetak
Human papillomavirus (HPV)-associated genital pathology is by definition an infectious disease. However, over the last decades, the oncogenic properties of HPV have been extensively studied. The aim of this study was to determine the frequency of certain HPV DNA types in men with clinically visible lesions consistent with HPV genital infection (condylomata acuminata, condylomata plana and giant condyloma of Buschke-Lowenstein), and to find out if there was a correlation between certain HPV DNA types and localization of HPV genital lesions. HPV DNA typing using PCR was performed on biopsy specimens taken from clinically visible lesions consistent with HPV genital infection of 100 male patients aged 3 to 68 years, attending the STD Clinic of the Department of Dermatology and Venerology, Zagreb University Hospital Center. Type-specific primers for low-risk HPV 6/11 and high risk HPV 16, 18, 31 and 33 were used in either single (HPV 18) or multiple (HPV 6/11 with HPV 16 and HPV 31 with HPV 33) PCR reaction. HPV DNA types 6/11 were found in 81 out of 100 patients. However, high-risk HPV DNA was found in 19 patients (HPV type 16 in 1 1 patients, HPV type 18 in 6 patients, and HPV 31 and 33 in one patient each). High-risk HPV DNA types were significantly more often located on the distal part of the skin and mucous membranes of the external genitalia (chi-square=36.307 ; p=3.841 E-07 ; DF=3). It can be concluded that HPV DNA types are not always absolutely consistent with the clinical type of HPV genital lesion, i.e. high-risk HPV DNA types can also be isolated from condylomata acuminata (and not only plana). Thus, we consider HPV detecting and typing of male genital HPV lesions as an important part of the diagnostic procedure, treatment and follow-up.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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