Naslov
Differences in percutaneous absorption in normal subjects and atopic dermatitis patients in relation to the molecular weight

Autori
Jakasa, Ivone ; Verberk, Maarten M ; Esposito, Maria ; Kezic, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Occupational and Environmental Exposures of Skin to Chemicals

Mjesto i datum
Stockholm, Švedska, 12.06.2005. - 15.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
percutaneous absorption; atopic dermatitis; molecular weight

Sažetak
The molecular weight (MW) plays a significant role in the percutaneous penetration of chemicals. It has been reported that in the compromised skin, the MW cut-off is shifted to the higher MW. Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperactivity to environmental triggers and is characterized by dry skin and increased transepidermal water loss. The objective of this study was to investigate the differences in percutaneous penetration of polyethylene glycols (PEGs) in subjects with normal skin barrier and subjects with the history of AD in relation to the molecular weight (MW). Twenty healthy subjects and twenty subjects with history of atopic dermatitis were exposed to water solution of PEGs in range of 150-590 Da for 6 hours on the volar forearm. After the end of exposure the stratum corneum (SC) was totally removed by means of tape stripping and the concentration of PEGs and proteins were determined in each strip. Using the Fick’ s second law of diffusion the permeation parameters were determined. The penetration of all PEGs into the SC was enhanced in the skin noninvolved by the disease of AD patients. This suggests that even the noninvolved skin in AD patients has a compromised barrier function.

Izvorni jezik
Engleski

POVEZANOST RADA