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Pregled bibliografske jedinice broj: 377149

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Aulchenko, Yurii S.; Ripatti, Samuli; Lindqvist, Ida; Boomsma, Dorret; Heid, Iris M.; Pramstaller, Peter P.; Penninx, Brenda W. J. H.; Janssens, A.; Cecile, J. W.; Wilson, James F. et al.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts // Nature Genetics, 41 (2009), 1; 47-55 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 377149 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Autori
Aulchenko, Yurii S. ; Ripatti, Samuli ; Lindqvist, Ida ; Boomsma, Dorret ; Heid, Iris M. ; Pramstaller, Peter P. ; Penninx, Brenda W. J. H. ; Janssens, A. ; Cecile, J. W. ; Wilson, James F. ; Spector, Tim ; Martin, Nicholas G. ; Pedersen, Nancy L. ; Kyvik, Kirsten Ohm ; Kaprio, Jaakko ; Hofman, Albert ; Freimer, Nelson B. ; Jarvelin, Marjo-Riitta ; Gyllensten, Ulf ; Campbell, Harry ; Rudan, Igor ; Johansson, Å sa ; Marroni, Fabio ; Hayward, Caroline ; Vitart, Veronique ; Jonasson, Inger ; Pattaro, Cristian ; Wright, Alan ; Hastie, Nick ; Pichler, Irene ; Hicks, Andrew A. ; Falchi, Mario ; Willemsen, Gonneke ; Hottenga, Jouke-Jan ; de Geus, Eco J. C. ; Montgomery, Grant W. ; Whitfield, John ; Magnusson, Patrik ; Saharinen, Juha ; Perola, Markus ; Silander, Kaisa ; Isaacs, Aaron ; Sijbrands, Eric J. G. ; Uitterlinden, Andre G. ; Witteman, Jacqueline C. M. ; Oostra, Ben A. ; Elliott, Paul ; Ruokonen, Aimo ; Sabatti, Chiara ; Gieger, Christian ; Meitinger, Thomas ; Kronenberg, Florian ; Döring, Angela ; Wichmann, H-Erich ; Smit, Johannes H. ; McCarthy, Mark I. ; van Duijn, Cornelia M. ; Peltonen, Leena

Izvornik
Nature Genetics (1061-4036) 41 (2009), 1; 47-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genetic loci; lipid levels; coronary heart disease; risk; European populations

Sažetak
Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17, 797&#8211; 22, 562 persons, aged 18&#8211; 104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 10-8), including 16 loci that were identified by previous GWA studies. The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 10-11 ; LDL, P = 2.6 10-10), TMEM57 (TC, P = 5.4 10-10), CTCF-PRMT8 region (HDL, P = 8.3 10-16), DNAH11 (LDL, P = 6.1 10-9), FADS3-FADS2 (TC, P = 1.5 10-10 ; LDL, P = 4.4 10-13) and MADD-FOLH1 region (HDL, P = 6 10-11). For three loci, effect sizes differed significantly by sex. Genetic risk scores based on lipid loci explain up to 4.8% of variation in lipids and were also associated with increased intima media thickness (P = 0.001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
KBC "Sestre Milosrdnice",
Medicinski fakultet, Split

Profili:

Avatar Url Igor Rudan (autor)

Citiraj ovu publikaciju:

Aulchenko, Yurii S.; Ripatti, Samuli; Lindqvist, Ida; Boomsma, Dorret; Heid, Iris M.; Pramstaller, Peter P.; Penninx, Brenda W. J. H.; Janssens, A.; Cecile, J. W.; Wilson, James F. et al.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts // Nature Genetics, 41 (2009), 1; 47-55 (međunarodna recenzija, članak, znanstveni)
Aulchenko, Y., Ripatti, S., Lindqvist, I., Boomsma, D., Heid, I., Pramstaller, P., Penninx, B., Janssens, A., Cecile, J. & Wilson, J. (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics, 41 (1), 47-55.
@article{article, author = {Aulchenko, Yurii S. and Ripatti, Samuli and Lindqvist, Ida and Boomsma, Dorret and Heid, Iris M. and Pramstaller, Peter P. and Penninx, Brenda W. J. H. and Janssens, A. and Cecile, J. W. and Wilson, James F. and Spector, Tim and Martin, Nicholas G. and Pedersen, Nancy L. and Kyvik, Kirsten Ohm and Kaprio, Jaakko and Hofman, Albert and Freimer, Nelson B. and Jarvelin, Marjo-Riitta and Gyllensten, Ulf and Campbell, Harry and Rudan, Igor and Johansson, and \#197 and Marroni, Fabio and Hayward, Caroline and Vitart, Veronique and Jonasson, Inger and Pattaro, Cristian and Wright, Alan and Hastie, Nick and Pichler, Irene and Hicks, Andrew A. and Falchi, Mario and Willemsen, Gonneke and Hottenga, Jouke-Jan and de Geus, Eco J. C. and Montgomery, Grant W. and Whitfield, John and Magnusson, Patrik and Saharinen, Juha and Perola, Markus and Silander, Kaisa and Isaacs, Aaron and Sijbrands, Eric J. G. and Uitterlinden, Andre G. and Witteman, Jacqueline C. M. and Oostra, Ben A. and Elliott, Paul and Ruokonen, Aimo and Sabatti, Chiara and Gieger, Christian and Meitinger, Thomas and Kronenberg, Florian and D\"{o}ring, Angela and Wichmann, H-Erich and Smit, Johannes H. and McCarthy, Mark I. and van Duijn, Cornelia M. and Peltonen, Leena}, year = {2009}, pages = {47-55}, keywords = {genetic loci, lipid levels, coronary heart disease, risk, European populations}, journal = {Nature Genetics}, volume = {41}, number = {1}, issn = {1061-4036}, title = {Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts}, keyword = {genetic loci, lipid levels, coronary heart disease, risk, European populations} }
@article{article, author = {Aulchenko, Yurii S. and Ripatti, Samuli and Lindqvist, Ida and Boomsma, Dorret and Heid, Iris M. and Pramstaller, Peter P. and Penninx, Brenda W. J. H. and Janssens, A. and Cecile, J. W. and Wilson, James F. and Spector, Tim and Martin, Nicholas G. and Pedersen, Nancy L. and Kyvik, Kirsten Ohm and Kaprio, Jaakko and Hofman, Albert and Freimer, Nelson B. and Jarvelin, Marjo-Riitta and Gyllensten, Ulf and Campbell, Harry and Rudan, Igor and Johansson, and \#197 and Marroni, Fabio and Hayward, Caroline and Vitart, Veronique and Jonasson, Inger and Pattaro, Cristian and Wright, Alan and Hastie, Nick and Pichler, Irene and Hicks, Andrew A. and Falchi, Mario and Willemsen, Gonneke and Hottenga, Jouke-Jan and de Geus, Eco J. C. and Montgomery, Grant W. and Whitfield, John and Magnusson, Patrik and Saharinen, Juha and Perola, Markus and Silander, Kaisa and Isaacs, Aaron and Sijbrands, Eric J. G. and Uitterlinden, Andre G. and Witteman, Jacqueline C. M. and Oostra, Ben A. and Elliott, Paul and Ruokonen, Aimo and Sabatti, Chiara and Gieger, Christian and Meitinger, Thomas and Kronenberg, Florian and D\"{o}ring, Angela and Wichmann, H-Erich and Smit, Johannes H. and McCarthy, Mark I. and van Duijn, Cornelia M. and Peltonen, Leena}, year = {2009}, pages = {47-55}, keywords = {genetic loci, lipid levels, coronary heart disease, risk, European populations}, journal = {Nature Genetics}, volume = {41}, number = {1}, issn = {1061-4036}, title = {Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts}, keyword = {genetic loci, lipid levels, coronary heart disease, risk, European populations} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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  • MEDLINE

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