Naslov
Sertraline and 5-HT markers in platelets of depressed patients

Autori
Muck-Šeler, Dorotea ; Pivac, Nela ; Šagud, Marina ; Jakovljević, Miro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XI World Congress of Psychiatry : Abstract Book ; Vol. II / - Hamburg : Word Psychiatry Association, 1999, 253-253

Skup
World Congress of Psychiatry (11 ; 1999)

Mjesto i datum
Hamburg, Njemačka, 06.08.1999. - 11.08.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platelet serotonin; platelet MAO; 3H-paroxetine binding; depressive disorders; sertraline

Sažetak
Serotonin (5-HT) may be involved in the pathophysiology of depressive disorders. The role of 5-HT in the etiology and treatment of depression was investigated using blood platelets as a peripheral model for central presynaptic serotonergic synaptosomes. The present study examines platelet 5-HT concentration, 3H-paroxetine binding and platelet monoamine oxidase (MAO) activity in 21 nonpsychotic, nonsuicidal depressed female patients (DSM-IV criteria), before (baseline, i.e. after 8 days of wash-out period) and during (4 and 24 weeks) treatment with sertraline ( a selective serotonergic reuptake inhibitor, SSRI). When compared to baseline levels, repeated administration of sertraline (25-100 mg daily) markedly decreased platelet 5-HT levels, and did not change 3H-paroxetine binding and platelet MAO activity. From 15 nonpsychotic depressed patients who finished 24-weeks treatment with sertraline, complete clinical improvement ( based on the reductions in HAMD and MADRS scores) was seen in 11 patients, whereas 4 patients showed partial clinical improvement. These results confirmed that alterations in 5-HT system are included in antidepressant action of sertraline.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA