Naslov
Liposome-encapsulated parvovirus vaccine for pig protection

Autori
Roić, Besi ; Lipej, Zoran ; Željko Mihaljević

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts XIV. International Congress of Virology, Istambul / - Istanbul, 2008, 293-293

Skup
XIV. International Congress of Virology

Mjesto i datum
Istanbul, Turska, 10.08.2008. - 15.08.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
parvovirus svinja; vakcina
(porcine parvovirus; swine; vaccine)

Sažetak
In this study, the protective potency of the liposomal vaccine was compared with that of commercially available inactivated oil vaccine Parvokal (Veterina Ltd. Zagreb, Croatia). Porcine parvovirus strain NADL-2 was propagated on porcine fetal kidney cells (PK-15) and the liposomal vaccine was prepared from whole and purified parvovirus particle incorporated into liposome. The procedure was based on dehydration and controled rehidration to induce fusion of perforemed liposomes. Twenty Swedish Landrace gilts were vaccinated 6 weeks before mating and revaccinated after 2 weeks with 2 ml of the liposomal vaccine i.m. Second group of animals was vaccinated with 2 ml of comercial vaccine i.m. Specific immune response eas measured by the hemagglutination inhibition tes and ELISA. The antibody lavel generated by liposomal vaccine induced a good protective immune response similar to those generated by the licenced vaccine. These results indicate that vaccines prepareted in the form of liposomes represent a step toward as safe and ecologically convenient vaccine.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA