Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter

Salopek, Daniela; Grčević, Danka; Katavić, Vedran; Kovačić, Nataša; Lukić, Ivan Krešimir; Marušić, Ana

doi:10.1016/j.imlet.2008.10.002

Pregled bibliografske jedinice broj: 375432

Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter

Salopek, Daniela; Grčević, Danka; Katavić, Vedran; Kovačić, Nataša; Lukić, Ivan Krešimir; Marušić, Ana

Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter // Immunology letters, 121 (2008), 2; 134-139 doi:10.1016/j.imlet.2008.10.002 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 375432 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter

Autori
Salopek, Daniela ; Grčević, Danka ; Katavić, Vedran ; Kovačić, Nataša ; Lukić, Ivan Krešimir ; Marušić, Ana

Izvornik
Immunology letters (0165-2478) 121 (2008), 2; 134-139

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone phenotype; Interleukin-7; transgenic mice; osteoclasts; osteoblasts

Sažetak
Mice with interleukin (IL)-7 transgene under the control of Eα promoter over-express IL-7 in MHC class II-positive cells and develop specific immune phenotype, marked by an increase in CD45R+ cells in both the bone marrow and peripheral blood. We show that IL-7 transgenic mice have a bone phenotype characterized by an age-related loss of trabecular bone in both axial and long bones. Osteopenia was the result of increased number of active osteoclasts on the surface of trabecular bone. Furthermore, IL-7 transgenic mice showed increased osteoclastic but unchanged osteoblastic potential of the bone marrow in vitro. IL-7 over-expression also created osteoclastogenic microenvironment within the bone marrow which promoted the commitment of precursors towards the osteoclast lineage. These findings are important for immunological disturbances where IL-7 is involved and where alterations in the immune system are accompanied by changes in bone metabolism, such as multiple myeloma, rheumatoid arthritis and postmenopausal osteoporosis

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
108-1080229-0142 - Molekularni mehanizmi učinaka imunosnih poremećaja na kost (Grčević, Danka, MZOS ) ( CroRIS)
108-1080229-0341 - B limfociti, makrofagi i podrijetlo osteoklasta (Katavić, Vedran, MZOS ) ( CroRIS)
108-1080229-0140 - Molekularne interakcije koštanog i imunološkog sustava (Marušić, Ana, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Daniela Žitnjak (autor)