Pregled bibliografske jedinice broj: 375198
Enzyme-Catalysed Nucleophilic Ring Opening of Epoxides for the Preparation of Enantiopure Tertiary Alcohols
Enzyme-Catalysed Nucleophilic Ring Opening of Epoxides for the Preparation of Enantiopure Tertiary Alcohols // Advanced synthesis & catalysis, 349 (2007), 14-15; 2279-2285 doi:10.1002/adsc.200700146 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 375198 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Enzyme-Catalysed Nucleophilic Ring Opening of Epoxides for the Preparation of Enantiopure Tertiary Alcohols
Autori
Majerić Elankov, Maja ; Hoeffken, Wolfgang H. ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.
Izvornik
Advanced synthesis & catalysis (1615-4150) 349
(2007), 14-15;
2279-2285
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
azides ; cyanides ; epoxides ; halohydrin dehalogenase ; tertiary alcohols
Sažetak
The halohydrin dehalogenase from Agrobacterium radiobacter AD1 catalyzes nucleophilic ring opening of epoxides with cyanide and azide. In the case of 2, 2-disubstituted epoxides, this reaction proceeds with excellent enantioselectivity (E values up to>200), which gives, by kinetic resolution, access to various enantiopure epoxides and b-substituted tertiary alcohols (ee up to 99%). Since the enzyme has a broad substrate range and because these tertiary alcohols are difficult to prepare in other ways, HheC is an attractive biocatalyst for the production of b-cyano and b-azido tertiary alcohols.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
