Naslov
Medullary breast carcinoma in association with lymphocytic lobulitis

Autori
Dekanić, Andrea: Štifter, Sanja: Lovasić, Ingrid:Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Knjiga sažetaka / - , 2008, 65-65

Skup
4.Hrvatski kongres patologa i sudskih medicinara s međunarodnim sudjelovanjem

Mjesto i datum
Osijek, Hrvatska, 25.09.2008. - 28.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Medullary breast carcinoma; lymphocytic lobulitis

Sažetak
We present a case of 57-years old woman with a partial mastectomy on the right and the excision biopsy on the left side, due to mammographicaly suspected malignant breast lesions. Pathohistological findings were medullary breast carcinoma with lymphocytic lobulitis on the right breast, and microcalcificationes with severe lymphocytic lobulitis on the left breast. She was also in high risk of hereditary breast cancer due to familiar anamnesis. This rare association of lymphocytic lobulitis and medullary carcinoma suggests an possible autoimmune pathogenesis. This condition has been associated with diabetes mellitus, autoimmune thyroiditis and artropathy. In contrary, the medullary carcinoma is relatively rarely diagnosed histotype of cancer. It comprises five to seven percent of all breast carcinoma. Preliminary observations indicate in such rare lesions predominance of T-lymphocytes. It is already known that frequent presence of lymphocytic infiltration in hereditary ductal in situ and infiltrating ductal/medullary carcinomas is associated with an immune reaction to an unidentified antigen. This condition has been observed in women at hereditary high risk of breast cancer, possibly as part of an early carcinogenic event. Because of the rareness of this type of lesions we consider it to be of importance to further analyze lymphocytic infiltrate and to conduct molecular studies of tumor antigens associated with it. It is necessary to define the mechanisms behind this immune response. Immunotherapy as stimulation of an immune response could possibly prevent occurrence more advanced lesions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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