Naslov
Reversible brain atrophy in patients with Cushing's disease

Autori
Gnjidić, Živko ; Sajko, Tomislav ; Kudelić, Nenad ; Malenica, Maša ; Vizner, Branka ; Vrkljan, Milan ; Hat, Josip ; Rumboldt, Zoran

Izvornik
Collegium antropologicum (0350-6134) 32 (2008), 4; 1165-1170

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cushing’ s disease ; brain atrophy ; pituitary ACTH adenoma ; hypercortisolism ; transsphenoidal surgery ; CT ; MRI ; reversibility

Sažetak
During the past 25 years, we came across 60 patients with corticotroph pituitary adenomas and Cushing’ s disease. Neuroradiological examination showed prominent volume loss of the brain parenchyma, unexpected for the patient’ s age. This » brain atrophy« appeared to regress after surgical removal of pituitary adenoma and normalization of cortisol level. Observed difference between degree of » brain atrophy« in the Cushing’ s disease group and in the control group was statistically significant (p<0.001). The degree of » brain atrophy« correlated well with the duration of Cushing’ s disease. Partial reversibility of » brain atrophy« was noticed during the 2nd, 3rd and 4th year after surgery and normalization of cortisol level. Increased cortisol level is one of the causative factors in pathogenesis of » brain atrophy« . Loss of brain volume is at least partially reversible after normalization of cortisol levels.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA