Naslov
Recombinant factor VIIa in massive haemoptysis associted with chronic necrotising Aspergillosis

Autori
Samaržija, Miroslav ; Srdić, Dražena ; Redžepi, Gzim ; Pleština, Sanja ; Mažuranić, Ivica ; Jakopović, Marko ; Miculinić, Neven

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), 3; 999-1002

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
haemoptysis; recombinant activated factor VII; pulmonary aspergillosis

Sažetak
The successful use of recombinant activated factor VII (rFVIIa), in treating massive, life-threatening haemoptysis in a 55-year-old male patient with chronic necrotising aspergillosis, is reported. Patient diagnosed with chronic necrotising aspergillosis three months ago was admitted to our department with massive haemoptysis. Patient was treated as outpatient with itraconazole. One day post-admission, two doses of rFVIIa (30 mg· kg– 1) were administered and the haemoptysis was successfully resolved. Two further doses of rFVIIa (30 mg· kg– 1) were given the following day, and after that there were no more recurrences of pulmonary haemorrhage. No thromboembolic or other adverse events were observed following rFVIIa therapy. Our findings suggest that use of rFVIIa may represent a safe and effective treatment choice for patients with haemoptysis due to aspergillosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA