Naslov
IgA mediated pemphigus precipitated by glibenclamide – a case report

Autori
Rošin Grget, Kata ; Brailo, Vlaho ; Mravak-Stipetić, Marinka ; Marinović, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract of the 9th biennial Congress of the European Association of Oral Medicine ; u: Oral Diseases 14 (2008) (S1) ; Poster Abstracts (14–43) / Baum, Bruce ; Scully, Crispian - Salzburg : Wiley-Blackwell, 2008, 36-36

Skup
Biennial Congress of the European Association of Oral Medicine (9 ; 2008)

Mjesto i datum
Salzburg, Austrija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pemphigus; glibenclamide

Sažetak
Pemphigus is autoimmune disease characterized by epithelial blistering affecting cutaneous and /or mucosal surfaces. Pemhigus might be outcome of the interaction between endogenous (genetic) and exogenous factors (such as drugs). Drugs most commonly associated with pemphigus are divided into three groups according their chemical structure: thiol drugs (sulfhydryl (SH)-containing) ; phenol drugs ; and nonthiol nonphenol drugs. We present a case of pemphigus developed after treatment with glibenclamide which is not exactly a thiol drug but has sulfur (S-) in its molecule. Chief complaint: 80 year old patient came to the Department of Oral medicine complaining of gingival soreness which lasted for 6 months. His medical history revealed hypertension and diabetes mellitus for which he was taking amlodipine and glibenclamide. Clinical examination revealed gingival erosions in his lower left molar area and intense redness in lower frontal gingival. Clinical presentation was consistent with desquamative gingivitis. Gingival biopsy was performed for histology and direct immunofluorescence. Histology was not specific, revealing mixed inflammatory infiltrate without acantholysis. Direct immunofluorescence revealed intercellular deposits of IgA. The finding was consistent with the diagnosis of Ig A mediated pemphigus. Patient was prescribed betamethasone propionate in orabase and chlorhexidine solution 3 times daily for his lesions. New antidiabetic drug (metformin) was introduced. His lesions slowly healed within two months. Three months later at first recall, patient was asymptomatic. Our case confirmed that "masked" thiol drugs (glibenclamide) could be involved in the pathogenesis of pemphigus.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

Napomena
DOI: 10.1111/j.1601-0825.2008.01481.x

POVEZANOST RADA