Naslov
BETA STIFNESS INDEX IN PATIENTS WITH DEMENTIA

Autori
Jurasic, Miljenka-Jelena ; Martinic Popovic, Irena ; Morovic, Sandra ; Trkanjec, Zlatko ; Šerić, Vesna ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurologia Croatica 57 (Suppl. 4) / Šimić, Goran ; Mimica, Ninoslav ; Petravić, Damir - Zagreb : Denona, 2008

Skup
4th Croatian Congress on Alzheimer's disease with international participation

Mjesto i datum
Rovinj, Hrvatska, 08.10.2008. - 11.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
vascular; Beta Stiffness index; Alzheimer’ s disease

Sažetak
Background and aim: Changes of arterial stiffness indicate alteration in arterial mechanics predisposing to the evolution of vascular end events, such as increased stroke occurrence. The aim of this study was to explore whether beta stiffness index could be selected to monitor pathomorphologic vascular changes in demented patients. Patients and methods: There were 38 patients included in this study ; 16 with Alzheimer&#8217; s disease (AD) and 22 with vascular dementia (VAD): 22 women and 16 men, aged 72, 53 +- 7, 87 yrs. Control group consisted of 33 clinically healthy controls (25 women and 8 men), aged 68, 85 +- 3, 52 yrs. Risk factors were noted and ultrasound measurements on common carotid artery (CCA) were performed using Aloka ProSound ALPHA 10 with 13 MHz linear probe. Results: Twenty-four patients had arterial hypertension, 9 had atrial fibrillation, 3 had diabetes and 18 had hyperlipoproteinaemia. In controls, hypertension was present as a single risk factor in 15 subjects. Average body mass index was 26, 14 +- 3, 89 kg/m2, and there were no significant differences compared the control group. Average blood pressure was 135, 58 +- 20, 48 mmHg over 78, 53 +-10, 42 mmHg, differing significantly in diastole with the control group. Mean intima media thickness (IMT) was 0, 84 +- 0, 27 mm and average CCA diameter was 8, 63 +- 1, 43 (right CCA), 8, 37 +- 1, 30 (left CCA), which were significantly higher than in controls (p< 0.05). Mean Beta Stiffness was 10, 71 +- 4, 95 (right CCA), 11, 56 +-6, 51 (left CCA), also significantly higher than in controls (p< 0.05). Conclusions: Both systolic and diastolic CCA diameter as well as beta stiffness index were significantly lower in non-demented subjects. As vascular changes are present in both AD and VAD , parameters like diameter change and beta stiffness index could be useful in preliminary assessment and follow-up of patients with cognitive decline.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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