Naslov
Differences in percutaneous absorption in normal and atopic dermatitis skin in relation to molecular weight

Autori
Jakasa, Ivone ; Verberk, Maarten M ; Esposito, Maria ; Bos, Jan D ; Kezic, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Investigative Dermatology / - , 2005

Skup
4th Georg Rajka International Symposium on Atopic Dermatitis

Mjesto i datum
Arcachon, Francuska, 2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
tape stripping; atopic dermatitis; stratum corneum; polyethylene glycol; skin permeability

Sažetak
Molecular weight plays a significant role in the percutaneous penetration of chemicals. Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperactivity to environmental triggers and is characterized by dry skin and increased transepidermal water loss. Percutaneous penetration of chemicals and drugs might be higher not only in involved but also in non-involved skin of atopic dermatitis patients. The objective of this study was to investigate the differences in percutaneous penetration of polyethylene glycol (PEGs) in subjects with normal skin barrier and subjects with the history of atopic dermatitis in relation to the molecular weight. Twenty healthy and twenty subjects with history of atopic dermatitis were exposed to water solution of PEGs in range of 150– 590 Da for 6 hours on the volar forearm. After the end of exposure the stratum corneum was totally removed by means of tape stripping and the concentration of PEGs and proteins were determined in each strip. Using Fick’ s second law of diffusion the permeation parameters were determined. The penetration of all PEGs into the stratum corneum was enhanced in non-involved skin of atopic dermatitis patients. This suggests that even the non-involved skin in atopic dermatitis patients has a compromised barrier function.

Izvorni jezik
Engleski

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