Naslov
Altered penetration of polyethylene glycols into compromised skin

Autori
Jakasa, Ivone ; Verberk, Maarten M ; Kezic, sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Toxicology letters / - , 2006

Skup
43rd Congress of The European Societies of Toxicology and 6th Congress of Toxicology in Developing Countries

Mjesto i datum
Zagreb, Hrvatska, 20.09.2006. - 24.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
polyethylene glycol; atopic dermatitis; skin permeation; stratum corneum

Sažetak
The human skin acts as an important, but only partial barrier to exogenous compounds. Most of the available skin permeability data are from normal intact human and animal skin. Data on permeability of chemicals in the compromised skin, in particular in humans in vivo, are scarce. The objective of this study was to investigate the differences in percutaneous penetration of polyethylene glycols (PEG) in subjects with normal and compromised skin in relation to molecular weight (MW). Two models of compromised skin were investigated: skin damaged with detergent sodium lauryl sulphate (SLS) and skin of patients with atopic dermatitis (AD). Twenty healthy subjects and 20 AD patients were exposed on the volar forearm to PEGs (MW of 150– 590 Da) for 6 h. After the end of exposure the stratum corneum (SC) was totally removed by means of tape stripping and the concentration ofPEGswere determined in each strip. Using the solution to the Fick’ s second law of diffusion the penetration parameters were deduced. The diffusion of PEGs decreased with the increasing MW in normal skin, skin of AD patients and SLS compromised skin. Both models of compromised skin showed increased diffusion of PEGs compared to controls. The partition coefficient showed no MW dependence in normal and AD skin ; however, in the skin compromised by SLS the partitioning showed unexplained increase with increasing MW. The studies on percutaneous penetration of PEGs demonstrated altered skin barrier in SLS compromised skin and in the skin of AD patients which was visibly not affected by disease. Compromised skin showed not only increases absorption, but facilitated entrance of larger molecules which normally would not be able to pass through the skin. Since a compromised skin barrier due to environmental damage or skin disease is not uncommon, when evaluating the health risk associated with skin exposure, penetration of higher molecular weight compounds should be considered.

Izvorni jezik
Engleski

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