Pregled bibliografske jedinice broj: 373439
Evaluation of in vivo animal and in vitro models for percutaneous absorption using human in vivo data
Evaluation of in vivo animal and in vitro models for percutaneous absorption using human in vivo data // Toxicology letters
Zagreb, Hrvatska, 2006. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Evaluation of in vivo animal and in vitro models for percutaneous absorption using human in vivo data
Autori
Jakasa, Ivone
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Toxicology letters
/ - , 2006
Skup
43rd Congress of The European Societies of Toxicology and 6th Congress of Toxicology in Developing Countries, Satellite Symposium: Dermal Exposure to Chemicals and Health Risk Assessment
Mjesto i datum
Zagreb, Hrvatska, 20.09.2006. - 24.09.2006
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
percutaneous penetration; in vivo; in vitro; biological monitoring
Sažetak
Reliable data on percutaneous penetration (PP) of chemicals are increasingly needed. Due to practical and ethical considerations it is impossible to measure dermal permeation in humans in-vivo for the many thousands of industrial chemicals in use today. Alternative approaches to predict PP comprise in-vivo animal models, in-vitro assays and quantitative structure– activity relationships (QSARs). However, the main obstacle in the wider use of these predictive models for health risk assessment is the lack of their validation. Human data on PP which form a golden standard for evaluation of these alternative methods are scarce. In addition, only a limited number of human in-vivo studies have been designed for actual in vitro– in vivo comparisons, and data were often generated under different experimental conditions. In the presentation, the design of parallel in vivo– in vitro studies with the emphasis on the data analysis and experimental conditions will be addressed. Using data on PP of 2-butoxyethanol, assessed both in-vivo and in-vitro in human and rat skin, factors influencing the results will be discussed. Furthermore, the importance of the volunteer experiments in generating relevant data for human risk assessment as well as the development and implementation of biological monitoring in occupational settings will be highlighted.
Izvorni jezik
Engleski
