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Pregled bibliografske jedinice broj: 371861

Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice // Book of Abstracts
Osijek, 2008. str. 82-82 (poster, nije recenziran, sažetak, znanstveni)

CROSBI ID: 371861 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice

Autori
Domitrović, Robert ; Jakovac, Hrvoje ; Grebić, Damir ; Milin, Čedomila ; Radošević-Stašić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - Osijek, 2008, 82-82

ISBN
978-953-95551-2-0

Skup
HDBMB2008, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation

Mjesto i datum
Osijek, Hrvatska, 17.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
carbon tetrachloride; hepatotoxicity; luteolin; mettalothionein; trace elements and minerals; mice

Sažetak
The aim of this study was to investigate the protective effect of luteolin on liver trace element and mineral content in mice with carbon tetrachloride (CCl4)-induced hepatotoxicity. Additionally, liver metallothionein (MT) expression was studied immunohistologically. Luteolin was administered intraperitoneally (i.p.) as a single 5 or 50 mg/kg dose, or once daily for 2 consecutive days, respectively. Two hours after the last injection, the mice were treated with CCl4 (20 mg/kg, i.p.). CCl4 injection reduced hepatic level of all metals except Ca, with an intense cytoplasmic staining pattern in hepatocytes located in periportal areas, indicating induction of MT. Pretreatment with 50 mg/kg of luteolin for 2 d remarkably elevated metal content to control values (Mg and Cu) and even above them (Zn and Fe). Luteolin pretreatment increased pericentral MT immunopositivity and histological architecture improvement in a time and dose-dependent manner, being the most prominent in mice pretreated with 50 mg/kg for 2 d. The liver in this group showed pronounced MT expression in almost all hepatocytes throughout the liver parenchyma. In conclusion, these results suggest the protective effect of luteolin on CCl4-induced hepatotoxicity and an enhancement of hepatocyte proliferative capabilities.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( CroRIS)
062-0621341-0061 - Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva. (Milin, Čedomila, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Biserka Radošević-Stašić (autor)

Avatar Url Čedomila Milin (autor)

Avatar Url Robert Domitrović (autor)

Avatar Url Hrvoje Jakovac (autor)

Avatar Url Damir Grebić (autor)

Citiraj ovu publikaciju:

Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice // Book of Abstracts
Osijek, 2008. str. 82-82 (poster, nije recenziran, sažetak, znanstveni)
Domitrović, R., Jakovac, H., Grebić, D., Milin, Č. & Radošević-Stašić, B. (2008) Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice. U: Book of Abstracts.
@article{article, author = {Domitrovi\'{c}, Robert and Jakovac, Hrvoje and Grebi\'{c}, Damir and Milin, \v{C}edomila and Rado\v{s}evi\'{c}-Sta\v{s}i\'{c}, Biserka}, year = {2008}, pages = {82-82}, keywords = {carbon tetrachloride, hepatotoxicity, luteolin, mettalothionein, trace elements and minerals, mice}, isbn = {978-953-95551-2-0}, title = {Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice}, keyword = {carbon tetrachloride, hepatotoxicity, luteolin, mettalothionein, trace elements and minerals, mice}, publisherplace = {Osijek, Hrvatska} }
@article{article, author = {Domitrovi\'{c}, Robert and Jakovac, Hrvoje and Grebi\'{c}, Damir and Milin, \v{C}edomila and Rado\v{s}evi\'{c}-Sta\v{s}i\'{c}, Biserka}, year = {2008}, pages = {82-82}, keywords = {carbon tetrachloride, hepatotoxicity, luteolin, mettalothionein, trace elements and minerals, mice}, isbn = {978-953-95551-2-0}, title = {Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice}, keyword = {carbon tetrachloride, hepatotoxicity, luteolin, mettalothionein, trace elements and minerals, mice}, publisherplace = {Osijek, Hrvatska} }

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