Naslov
The role of the cerebrospinal fluid biomarkers in a tertiary memory clinic: our 4-year experience

Autori
Boban, Marina ; Grbić, Kristina ; Mladinov, Mihovil ; Hof, Patrick ; Suessmair, Christine ; Ackl, Nibal ; Bader, Benedict ; Danek, Adrian ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica 57 (Suppl. 4) / Šimić, Goran ; Mimica, Ninoslav ; Petravić, Damir - Zagreb : Denona, 2008, 80-80

Skup
4th Croatian Congress on Alzheimer's disease with international participation

Mjesto i datum
Rovinj, Hrvatska, 08.10.2008. - 11.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
aging ; Alzheimer's disease ; cerebrospinal fluid ; cognition ; dementia ; diagnosis ; mild cognitive impairment ; tau proteins

Sažetak
Background: Alzheimer's disease (AD) is the most prevalent type of dementia. Although diagnostic markers for AD have been continuously improving, they still do not guarantee a definite diagnosis. However, it is safe to say that known biological markers from cerebrospinal fluid (CSF) can differentiate AD from other primary causes of dementia with high reliability and validity. As such, they were recently, together with structural and functional neuroimaging and genetic testing, included as an ancillary method in the clinical diagnostic criteria for AD. Objective: To assess the usability of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau-181) and beta-amyloid in a mixed population of patients with suspected dementia referred to a tertiary memory clinic. Patients and methods: Fifty-four consecutive patients with various primary causes of the dementia syndrome were included in the study. A retrospective diagnosis was established using the consensus criteria without prior knowledge of the CSF results. Lumbar puncture was performed as a part of the routine clinical workup. Levels of t-tau, p-tau-181 and beta-amyloid in CSF were measured using commercially available ELISA kits from Innogenetics, Ghent, Belgium and Biosource International, Camarillo, CA, USA. Results: Except for beta-amyloid, the overall sensitivity of the other two markers for diagnosis of AD was in range from 77 to 92%.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA