Naslov
Serotonin transporter gene and alcoholism : an association study using family based design

Autori
Schwab, S.G. ; Hranilović, Dubravka ; Trixler, M. ; Knapp, M. ; Jernej, Branimir ; Franke, P. ; Lichtermann, D. ; Maier, W. ; Wildenauer, D.B.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 7th World Congress of Psychiatric Genetics : Abstracts of Presentations ; u: Molecular psychiatry. Supplement 4 (1999) (S1) / - Basingstoke : New York (NY) : Stockton Press, 1999, S7-S7

Skup
World Congress of Psychiatric Genetics (7 ; 1999)

Mjesto i datum
Monterey (CA), Sjedinjene Američke Države, 14.10.1999. - 18.10.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
serotonin transporter; gene polymorphism; alcoholism

Sažetak
Alcoholism is a devastating disorder affecting up to 10% of the general population. Besides environmental factors, contribution of genetic factors has been suggested by twin-, family- and adoption studies. Genes coding for components of the dopaminergic and/or the serotonergic system may play a role in the development of alcoholism. A polymorphism in the 59 – flanking regulatory region of the serotonin transporter (5-HTT) that results in allelic variation of 5-HTT expression has been described recently. The polymorphism consists of a repetitive element. In caucasians, the most frequent alleles have 14(s-allele) or 16 (l-allele) repeats. We have used a familybased design for the analysis of this polymorphism in order to avoid stratification problems. Ninety-four alcoholics with their parents have been genotyped for the promotor polymorphism of the 5-HTT gene. Seventy-two of these simplex families were ascertained in Germany, 22 in Hungary (Pecs). Using TDT-statistics, we observed that the s-allele was preferentially transmitted 64 times as opposed to 36 times non-transmitted (TDT = 7.84, corrected P-value = .0064). We conclude, that the s-allele of the serotonin transporter gene might have an impact on the development of alcohol dependence.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA