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Pregled bibliografske jedinice broj: 37088

Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test

Hranilović, Dubravka; Schwab, S.G.; Jernej, Branimir; Knapp, M.; Lerer, B.; Kanyas, K.; Borrmann, M.; Lichtermann, B.; Maier, W.; Wildenauer, D.B.
Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test // The 7th World Congress of Psychiatric Genetics : Abstracts of Presentations ; u: Molecular psychiatry. Supplement 4 (1999) (S1)
Basingstoke : New York (NY): Stockton Press, 1999. str. S23-S23 (predavanje, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 37088 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test

Autori
Hranilović, Dubravka ; Schwab, S.G. ; Jernej, Branimir ; Knapp, M. ; Lerer, B. ; Kanyas, K. ; Borrmann, M. ; Lichtermann, B. ; Maier, W. ; Wildenauer, D.B.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 7th World Congress of Psychiatric Genetics : Abstracts of Presentations ; u: Molecular psychiatry. Supplement 4 (1999) (S1) / - Basingstoke : New York (NY) : Stockton Press, 1999, S23-S23

Skup
World Congress of Psychiatric Genetics (7 ; 1999)

Mjesto i datum
Monterey (CA), Sjedinjene Američke Države, 14.10.1999. - 18.10.1999

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
5HT transporter; gene polymorphism; schizophrenia

Sažetak
The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a candidate for vulnerability to psychiatric disorders. Two polymorphic sites of the 5-HT transporter gene – 5-HTTLPR: a VNTR in the 59 regulatory region, and a VNTR in the second intron – were studied in a sample of 61 families for association and linkage with schizophrenia by the transmission disequilibrium test (TDT). Each family contained at least two siblings affected with schizophrenia or schizoaffective disorder (mainly schizophrenic). 133 affected offspring, with parental information for genotyping, were available for analysis. No preferential transmission of either short or long alleles of the promoter polymorphism was observed. However, a transmission distortion was detected for alleles of the intronic VNTR polymorphism (x2 TDTmax = 14.33 ; p=0.0002 ; corrected p value = 0.0003), resulting in more frequent than expected transmission of the 12 repeat allele. This finding adds additional evidence to the idea that the serotonergic system may be involved in development of psychoses.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
00980002

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Dubravka Hranilović (autor)

Citiraj ovu publikaciju:

Hranilović, Dubravka; Schwab, S.G.; Jernej, Branimir; Knapp, M.; Lerer, B.; Kanyas, K.; Borrmann, M.; Lichtermann, B.; Maier, W.; Wildenauer, D.B.
Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test // The 7th World Congress of Psychiatric Genetics : Abstracts of Presentations ; u: Molecular psychiatry. Supplement 4 (1999) (S1)
Basingstoke : New York (NY): Stockton Press, 1999. str. S23-S23 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Hranilović, D., Schwab, S., Jernej, B., Knapp, M., Lerer, B., Kanyas, K., Borrmann, M., Lichtermann, B., Maier, W. & Wildenauer, D. (1999) Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test. U: The 7th World Congress of Psychiatric Genetics : Abstracts of Presentations ; u: Molecular psychiatry. Supplement 4 (1999) (S1).
@article{article, author = {Hranilovi\'{c}, Dubravka and Schwab, S.G. and Jernej, Branimir and Knapp, M. and Lerer, B. and Kanyas, K. and Borrmann, M. and Lichtermann, B. and Maier, W. and Wildenauer, D.B.}, year = {1999}, pages = {S23-S23}, keywords = {5HT transporter, gene polymorphism, schizophrenia}, title = {Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test}, keyword = {5HT transporter, gene polymorphism, schizophrenia}, publisher = {Stockton Press}, publisherplace = {Monterey (CA), Sjedinjene Ameri\v{c}ke Dr\v{z}ave} }
@article{article, author = {Hranilovi\'{c}, Dubravka and Schwab, S.G. and Jernej, Branimir and Knapp, M. and Lerer, B. and Kanyas, K. and Borrmann, M. and Lichtermann, B. and Maier, W. and Wildenauer, D.B.}, year = {1999}, pages = {S23-S23}, keywords = {5HT transporter, gene polymorphism, schizophrenia}, title = {Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings as obtained by transmission disequilibrium test}, keyword = {5HT transporter, gene polymorphism, schizophrenia}, publisher = {Stockton Press}, publisherplace = {Monterey (CA), Sjedinjene Ameri\v{c}ke Dr\v{z}ave} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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