Naslov
Inhibition and activation of cholinesterases by substrates

Autori
Reiner, Elsa ; Simeon-Rudolf, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Life Sciences Conference 1999, Gozd Martuljek, Slovenija, Book of Abstracts and Programme / - Ljubljana : Slovensko farmacevtsko društvo, 1999

Skup
Life Sciences Conference 1999, Gozd Martuljek, Slovenija

Mjesto i datum
Gozd Martuljek, Slovenija, 18.09.1999. - 22.09.1999

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acetylcholinesterase; butyrylcholinesterase; catalytic constants; substrate inhibition; substrate activation

Sažetak
The relationship between activities and substrate concentrations (pS-curves) was analysed for reactions of acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8). Catalytic parameters Km, Kss, Vm, n and b were calculated from the Michaelis, Haldane, Hill and Webb equations in order to assess whether a given substrate also acts as an inhibitor or activator. It is suggested that the term substrate inhibition should only be attributed to substrates revealing bell-shaped pS-curves, while the terms apparent substrate inhibition or apparent substrate activation should relate to calculated values of the catalytic parameters.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA