Naslov
Posttraumatic stress disorder and platelet serotonin measures

Autori
Čičin-Šain, Lipa ; Mimica, Ninoslav ; Hranilović, Dubravka ; Balija, Melita ; Ljubin, Tajana ; Makarić, Gordan ; Folnegović-Šmalc, Vera ; Jernej, Branimir

Izvornik
Journal of psychiatric research (0022-3956) 34 (2000), 2; 155-161

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serotonin transporter; 5-HT uptake; platelets; monoamine oxidase; posttraumatic stress disorder

Sažetak
The role of serotonin (5HT) in the pathophysiology of posttraumatic stress disorder (PTSD) has been suggested by the overlap in clinical symptoms between PTSD and psychiatric conditions in which a serotonin dysfunction is implicated, as well as by the therapeutic efficiency of 5HT-related drugs (antidepressants, selective serotonin reuptake inhibitors and monoamine oxidase inhibitors) in alleviating symptoms in PTSD. In the present study the blood platelet, which has been proposed as a peripheral model for the central serotonergic neurons, has been used to search for alterations in 5HT mechanisms in PTSD. Platelet serotonin level and kinetics of serotonin transporter and monoamine oxidase (MAO-B) were assessed in 63 combat-related PTSD patients and 43 sex and age-matched control subjects. A significant reduction in maximal velocity of platelet MAO-B (approx. 30 %), with no changes in the enzyme affinity was observed in our patient sample. Conversely, no alterations in kinetic parameters (Vmax, Km) of platelet serotonin transporter as well as in platelet 5HT level were found in the PTSD group.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA