Naslov
Different diuretic response to non-steroidal and steroidal anti-inflammatory drugs

Autori
Turčić, Petra ; Samaržija Ita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd World Congress of the Board of Pharmaceutical Sciences of FIP (PSWC2007) ; Amsterdam, Netherland / - , 2007

Skup
3rd World Congress of the Board of Pharmaceutical Sciences of FIP (PSWC2007)

Mjesto i datum
Amsterdam, Nizozemska, 22.04.2007. - 25.04.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
kidney; inflammatory; steroid and non-steroid drugs

Sažetak
Various non-steroidal (NSAID) or steroidal (glucocorticoids) anti-inflammatory agents are often used to suppress inflammatory action in many diseases. The research in the field has shed new light on the side effects associated with these drugs. The aim of this study was to observe changes in diuretic response to NSAIDs and glucocorticoids because of the renal risk of exposure due to high intrarenal blood flow and drug concentration. The experiments were performed on Wistar rats of both sexes. Cumulative urine volume was collected inside separate metabolic cages during 24 hours of intraperitoneal drug administration.Results obtained with Na-diclofenac at a pharmacological dose (4 mg/kg body mass) showed a diuresis decrease by 18.2 5.2% as early as at 24 h (n=12). The experiments performed with indomethacin (2.8 mg/kg b.m.) also showed diuresis reduction by 12.0% 9% (n=5) at 24 h. Contrary to that, results obtained with a high dose of dexamethasone, a steroidal anti-inflammatory drug (40 mg/kg b.m.), indicated stimulation of diuresis, i.e. urine volume increased by 45 18% (n=12) at 24 h in comparison to control value. Study results showed NSAIDs such as diclofenac and indomethacin to cause diuresis reduction, whereas glucocorticoids such as dexamethasone led to an opposite effect (diuresis stimulation). The effect of NSAIDs might be interpreted as a consequence of intrarenal vasoconstriction caused by diminished vasodilatatory prostaglandins and modulation of tubular ion transport processes. Dexamethasone probably influenced some other processes involved in renal vasodilatation and tubular regulatory mechanisms, possibly binding to the high affinity mineralocorticoid receptor, thus reducing the actitvity of aldosterone and consequentially potentiating the diuretic effect. This effect would make glucocorticoids highly useful in conditions characterized by water retention.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA