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Pregled bibliografske jedinice broj: 369048

The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations

Džimbeg, Gabrijela; Zorc, Branka; Kralj, Marijeta; Ester, Katja; Pavelić, Krešimir; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 43 (2008), 6; 1180-1187 doi:10.1016/j.ejmech.2007.09.001 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 369048 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations

Autori
Džimbeg, Gabrijela ; Zorc, Branka ; Kralj, Marijeta ; Ester, Katja ; Pavelić, Krešimir ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Izvornik
European journal of medicinal chemistry (0223-5234) 43 (2008), 6; 1180-1187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiviral agents ; Antitumoral agents ; Primaquine ; Biologically active compounds ; Urea

Sažetak
The novel urea primaquine derivatives 3a– i were prepared by aminolysis of benzotriazolide 2 with the corresponding amine in the presence or absence of triethylamine. Compound 2 was prepared by acylation of primaquine with 1-benzotriazole carboxylic acid chloride. Among all compounds evaluated, the pyridine derivative 3h exhibited the best cytostatic activities against colon carcinoma, human T-lymphocyte and murine leukemia. However, this compound showed also rather marked cytotoxicity towards human normal fibroblasts. The highest selectivity in the inhibitory effects on human malignant tumor cell lines vs. normal fibroblasts was found for ureas 3c, 3d and 3g. Results of broad antiviral evaluation showed that pyridine and phenethyl derivatives of urea 3h and 3g exhibited some selective inhibition against cytomegalovirus.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Branka Zorc (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Katja Ester (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Džimbeg, Gabrijela; Zorc, Branka; Kralj, Marijeta; Ester, Katja; Pavelić, Krešimir; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 43 (2008), 6; 1180-1187 doi:10.1016/j.ejmech.2007.09.001 (međunarodna recenzija, članak, znanstveni)
Džimbeg, G., Zorc, B., Kralj, M., Ester, K., Pavelić, K., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E. & Mintas, M. (2008) The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry, 43 (6), 1180-1187 doi:10.1016/j.ejmech.2007.09.001.
@article{article, author = {D\v{z}imbeg, Gabrijela and Zorc, Branka and Kralj, Marijeta and Ester, Katja and Paveli\'{c}, Kre\v{s}imir and Andrei, Graciela and Snoeck, Robert and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2008}, pages = {1180-1187}, DOI = {10.1016/j.ejmech.2007.09.001}, keywords = {Antiviral agents, Antitumoral agents, Primaquine, Biologically active compounds, Urea}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2007.09.001}, volume = {43}, number = {6}, issn = {0223-5234}, title = {The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations}, keyword = {Antiviral agents, Antitumoral agents, Primaquine, Biologically active compounds, Urea} }
@article{article, author = {D\v{z}imbeg, Gabrijela and Zorc, Branka and Kralj, Marijeta and Ester, Katja and Paveli\'{c}, Kre\v{s}imir and Andrei, Graciela and Snoeck, Robert and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2008}, pages = {1180-1187}, DOI = {10.1016/j.ejmech.2007.09.001}, keywords = {Antiviral agents, Antitumoral agents, Primaquine, Biologically active compounds, Urea}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2007.09.001}, volume = {43}, number = {6}, issn = {0223-5234}, title = {The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations}, keyword = {Antiviral agents, Antitumoral agents, Primaquine, Biologically active compounds, Urea} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Elsevier BIOBASE
  • Current Awareness in Biological Sciences

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