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Pregled bibliografske jedinice broj: 368880

Alterations of Selected Genes in Human Testicular Germ Cell Tumors

Vladušić, Tomislav; Hrašćan, Reno; Krušlin, Božo; Gamulin, Marija; Grgić, Mislav; Vrhovac, Ivana; Franekić Čolić, Jasna
Alterations of Selected Genes in Human Testicular Germ Cell Tumors // European Environmental Mutagen Society, 38th Annual Meeting, Environmental Mutagenes and Human Health / Kirkland, David ; Franekić Čolić, Jasna: Garaj-Vrhovac, Verica (ur.).
Zagreb: EEMS/HGD, 2008. str. 260-260 (poster, međunarodna recenzija, sažetak, znanstveni)

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Naslov
Alterations of Selected Genes in Human Testicular Germ Cell Tumors

Autori
Vladušić, Tomislav ; Hrašćan, Reno ; Krušlin, Božo ; Gamulin, Marija ; Grgić, Mislav ; Vrhovac, Ivana ; Franekić Čolić, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Environmental Mutagen Society, 38th Annual Meeting, Environmental Mutagenes and Human Health / Kirkland, David ; Franekić Čolić, Jasna: Garaj-Vrhovac, Verica - Zagreb : EEMS/HGD, 2008, 260-260

Skup
European Environmental Mutagen Society, 38th Annual Meeting, Environmental Mutagenes and Human Health

Mjesto i datum
Cavtat, Hrvatska, 21.09.2008. - 25.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
testicular germ cell tumor; seminoma; nonseminoma; protoncogene; tumor suppressor gene; point mutation; loss of heterozygosity

Sažetak
Human testicular germ cell tumors are histologically heterogenous neoplasms with variable malignant potential. Two main types of germ cell tumors occur in men: seminomas and nonseminomas. In the present study a set of genes (protoncogene and tumor suppressor genes) was investigated in testicular cancers. K-ras protooncogene was tested for activating point mutations, and CDH1, APC, p53 and nm23-H1 tumor suppressor genes for loss of heterozygosity (LOH). Three seminomas and eight nonseminomas were analysed by PCR using restriction fragment length polymorphism, dinucleotide or tetranucleotide repeat polymorphism method. The results of our analysis showed that the most frequent changes were LOH of p53. Allelic loss of p53 was detected in three nonseminomas. Allelic losses of APC gene were present in one seminoma and one nonseminoma, whereas another seminoma and one nonseminoma showed LOH of CDH1. Analysis of heterozygosity has shown no consistent structural genetic alterations in tumor tissues. Although limited number of samples have been analysed so far, these findings are in accordance with the results of similar studies performed on testicular cancers.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA

Projekti:
058-0582261-2246 - Utjecaj mutagena i antimutagena na molekularne procese u stanici (Hrašćan, Reno, MZOS ) ( CroRIS)

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Profili:

Avatar Url Jasna Franekić (autor)

Avatar Url Marija Gamulin (autor)

Avatar Url Božo Krušlin (autor)

Avatar Url Reno Hrašćan (autor)

Avatar Url Tomislav Vladušić (autor)

Avatar Url Ivana Vrhovac Madunić (autor)

Citiraj ovu publikaciju:

Vladušić, Tomislav; Hrašćan, Reno; Krušlin, Božo; Gamulin, Marija; Grgić, Mislav; Vrhovac, Ivana; Franekić Čolić, Jasna
Alterations of Selected Genes in Human Testicular Germ Cell Tumors // European Environmental Mutagen Society, 38th Annual Meeting, Environmental Mutagenes and Human Health / Kirkland, David ; Franekić Čolić, Jasna: Garaj-Vrhovac, Verica (ur.).
Zagreb: EEMS/HGD, 2008. str. 260-260 (poster, međunarodna recenzija, sažetak, znanstveni)
Vladušić, T., Hrašćan, R., Krušlin, B., Gamulin, M., Grgić, M., Vrhovac, I. & Franekić Čolić, J. (2008) Alterations of Selected Genes in Human Testicular Germ Cell Tumors. U: Kirkland, D. & Franekić Čolić, Jasna: Garaj-Vrhovac, Verica (ur.)European Environmental Mutagen Society, 38th Annual Meeting, Environmental Mutagenes and Human Health.
@article{article, author = {Vladu\v{s}i\'{c}, Tomislav and Hra\v{s}\'{c}an, Reno and Kru\v{s}lin, Bo\v{z}o and Gamulin, Marija and Grgi\'{c}, Mislav and Vrhovac, Ivana and Franeki\'{c} \v{C}oli\'{c}, Jasna}, year = {2008}, pages = {260-260}, keywords = {testicular germ cell tumor, seminoma, nonseminoma, protoncogene, tumor suppressor gene, point mutation, loss of heterozygosity}, title = {Alterations of Selected Genes in Human Testicular Germ Cell Tumors}, keyword = {testicular germ cell tumor, seminoma, nonseminoma, protoncogene, tumor suppressor gene, point mutation, loss of heterozygosity}, publisher = {EEMS/HGD}, publisherplace = {Cavtat, Hrvatska} }
@article{article, author = {Vladu\v{s}i\'{c}, Tomislav and Hra\v{s}\'{c}an, Reno and Kru\v{s}lin, Bo\v{z}o and Gamulin, Marija and Grgi\'{c}, Mislav and Vrhovac, Ivana and Franeki\'{c} \v{C}oli\'{c}, Jasna}, year = {2008}, pages = {260-260}, keywords = {testicular germ cell tumor, seminoma, nonseminoma, protoncogene, tumor suppressor gene, point mutation, loss of heterozygosity}, title = {Alterations of Selected Genes in Human Testicular Germ Cell Tumors}, keyword = {testicular germ cell tumor, seminoma, nonseminoma, protoncogene, tumor suppressor gene, point mutation, loss of heterozygosity}, publisher = {EEMS/HGD}, publisherplace = {Cavtat, Hrvatska} }

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