Naslov
Successful use of recombinant activated factor VII in refractory gastrointestinal haemorrhage of unknown aetiology

Autori
Matić, Ivo ; Titlić, Marina ; Lučić, Ivan, Mirković, Ivo ; Jurjević, Matija

Izvornik
Bratislavské lekárske listy (0006-9248) 109 (2008), 10; 438-440

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gastrointestinal haemorrhage ; haemostatics ; laparotomy ; erythocyte transfusion

Sažetak
We report a 27-year-old patient who suffered severe gastrointestinal (GI) bleeding of unknown aetiology after undergoing elective abedominal surgery to remove a colonic tumour. Although the immediate postoperative recovery period was uneventful, rectal bleeding and signs of haemorrhagic shock developed within 10 hours of surgery. Nasogastric aspiration and laparotomy failed to reveal thecause of the GI haemorrhage, and the patient remained unresponsive to conventional haemostatic therapy. Treatment with a single dose of recombinant activated factor (rFVIIa) 45 ug/kg led to reduced bleeding, improvements in haemodynamic status, and reduced transfusion requirements. Although further investigation is warranted, our findings suggest that rFVIIa may be useful in the rescue treatment of severe GI haemorrhage of unknown origin.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA