Naslov
Brainstem raphe lesion recorded on transcranial sonography (TCS)

Autori
Budišić, Mislav ; Karlović, Dalibor ; Trkanjec, Zlatko ; Lovrenčić-Huzjan, Arijana ; Vuković, Vlasta ; Bene, Raphael ; Buljan, Danijel ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology, Vol.15, Suppl.3 / Lenzi, Gian Luigi ; Gil-Nagel, Antonio - Oxford : Wiley-Blackwell, 2008, 288-288

Skup
12th Congress of the European Federation of Neurological Societies

Mjesto i datum
Madrid, Španjolska, 23.08.2008. - 26.08.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
TCS; transcranial sonography; brainstem; nuclei raphe

Sažetak
Introduction: Numerous evidences from neuroimaging, biochemical and animal studies implicate basal limbic system involvement in the pathogenesis of mood disorders. Recent TCS studies showed that disruption of echogenic midbrain line corresponding to nuclei raphe might represent a functional marker for the development of depression. We initiated this study to replicate these findings in a group of unipolar depressed patients, suicidal patients and controls. Patients and methods: 31 patients with unipolar depression (DSMIV) of whom 11 were suicidal and 30 controls were studied using TCS. Severity of the disease was measured according to Hamilton Depression Rating Scale. Examination was performed by standardized semiquantative protocol by two independent physicians. Results: Reduced raphe echogenicity was found in 19 of 31 (63%) of the patients with unipolar depression but only in 3 (10%) controls. Furthermore, 9 of 11 (82%) suicidal patients exhibit the same reduced echogenicity, what was also in negative correlation with the severity of the illness assessed by HDRS cc=– 0.569, p=0.003. No correlation was found between raphe echogenicity and the number of depressive episodes, age, gender or duration of the disease. (p>0.05). We also found significant interobserver reliability for this method. Discussion: Our result showed that altered echogenicity of the mesencephalic midline, what corresponds to the nuclei raphe is frequent in patients with unipolar depression. Such finding is rare in healthy subjects ; however, in suicidal patients that finding was even more pronounced. These data suggest that TCS might be a novel method for the detection of depressive disorders and differentiating suicidal patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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