Naslov
DNA repair in radiation resistant bacterium Deinococcus radiodurans

Autori
Zahradka, Ksenija ; Slade, Dea ; Bailone, Adriana ; Sommer, Suzanne ; Averbeck, Dietrich ; Petranović, Mirjana ; Lindner, Ariel ; Radman, Miroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
HDBMB2008 Congress of the Croatian Society of Biochemistry and Molecular Biology With International Participation - Book of Abstracts / Strelec, Ivica ; Glavaš-Obrovac, Ljubica - Osijek : Hrvatsko Društvo za Biotehnologiju, 2008, 44-44

ISBN
978-953-95551-2-0

Skup
HDBMB2008 Congress of the Croatian Society of Biochemistry and Molecular Biology With International Participation

Mjesto i datum
Osijek, Hrvatska, 17.09.2008. - 20.09.2008

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Deinococcus radiodurans; DNA repair; homologous recombination; radiation

Sažetak
Deinococcus radiodurans, an extremophile bacterium, sustains extreme conditions of life, such as excessive desiccation and exposure to high doses of ionizing radiation. Both desiccation and radiation cause DNA double-strand breaks, the most severe form of genomic damage. Whereas most vegetative prokaryotic and eukaryotic cells can survive less than a dozen simultaneous double-strand DNA breaks, D. radiodurans survives extreme desiccation and ionizing radiation breaking its genome into hundreds of fragments. Remarkably, in just couple of hours, these fragments are reassembled into functional chromosomes due to an efficient and precise DNA repair process. We have found that genome reconstitution in D. radiodurans following gamma radiation involves a novel mechanism called "extended synthesis-dependent strand annealing", followed and completed by homologous recombination.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA