Naslov
Gastric ulcer and intestinal type of gastric carcinoma in relation to H. pylori infection and gastritis

Autori
Prskalo, Marija ; Katičić, Miroslava ; Dominis, Mara ; Džebro, Sonja ; Presečki, Vladimir ; Papa, Branko ; Čolić-Cvrlje, Vesna ; Šabarić, Branka ; Tićak, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Digestion (0012-2823) 59 (1998), supplement 3 / S.n. - , 1998, 453-453

Mjesto i datum
,

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; atrophic gastritis; gastric ulcer; intestinal type of gastric carcinoma

Sažetak
Aim: As gastric ulcer (GU) and intestinal type of gastric carcinoma (IGC) arise in the setting of multifocal atrophic gastritis, the aim of this study was to determine their H. pylori status (urease test, histology, and serology) and mucosal inflammatory response according to the Sydney classification. Methods: 60 consecutive patients with peptic GU, unrelated to the use of nonsteroidal anti-inflammatory drugs, and 40 patients with Lauren’s IGC were included. Categorical data were compared by chi-square test and numerical by Student’s test. Results: H. pylori infection was detected in all GU (60/100%) and most of IGC patients (32/80%), significantly more often found histologically and by urease test in the GU than IGC group (55/60 v 17/40 and 54/60 v 17/40, respectively). In seroprevalence, however, they didn’t differ significantly (55/60 v 31/40). In spite of the overall lower rate of histological detection in IGC patients, H. pylori infection was of greater density in them. Severity and activity of antral gastritis were more pronounced in GU than IGC patients and the opposite referred to body gastritis. Atrophy, intestinal metaplasia and epithelial dysplasia significantly prevailed in the IGC patients, either body or antral mucosa was concerned. Conclusions: We can conclude that there is a noticeable difference between GU and IGC in infection density and inflammatory and architectural changes across body and antral mucosa, mainly attributable to different outcomes of H. pylori infection.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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