Naslov
A new dual and triple therapies in eradicating Helicobacter pylori in peptic ulcer patients

Autori
Katičić, Miroslava ; Presečki, Vladimir ; Prskalo, Marija ; Tićak, Mirjana ; Čulig, Josip ; Pavić-Sladoljev, Dubravka ; Šabarić, Branka ; Dominis, Mara ; Kalenić, Smilja ; Marušić, Marinko ; Plečko, Vanda ; Džebro, Sonja ; Čolić-Cvrlje, Vesna ; Papa, Branko ; Naumovski-Mihalić, Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut (0017-5749) 43 (1998), supplement 2 / S.n. - , 1998, A86-A86

Mjesto i datum
,

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; ulcer; therapy; ranitidine bismuth citrate; azithromycin; amoxicillin

Sažetak
Aims: To assess the H. pylori (H.p) eradication rates following a dual therapy of ranitidine bismuth citrate (RBC) plus azithromycin (Az) and triple therapy of ranitidine bismuth citrate (RBC), azithromycin (Az) and amoxicillin (A). Objective: 90 patients (F/M 46/44, mean age 50), with H. pylori +ve gastric (14) and duodenal (76) ulcers were included in a open, randomized, controlled trial. Patients were randomized to receive either RBC 400mg bd. with Az 1g od. for 3 (Group A; N=20) and 7 days (Group B; N=25), or RBC 400 mg bd., Az 1g o.d. for 3 days and A 1g bd. for 7 days (Group C; N=20) and RBC 400 mg bd., Az 1g od. and A 1g bd. for 7 days (Group D; N=25). All four regimes were followed by 21 days of RBC 400 mg bd. Methods: H. pylori infection was initially detected by CLO-Test, histology and culture on antral and corpus biopsies and by 13C Urea Breath Test (UBT). A second endoscopy was performed 4 weeks after the end of therapy for the assessment of ulcer healing and H. pylori infection. Eradication was assumed if all the tests (CLO-Test, histology, culture and 13C UBT) were negative for H. pylori. Results: 89 patients (99%) completed the study. The eradication rates (ER) and healing rates (HR) according to Intention to Treat (ITT) and Per Protocol (PP) analyses are summarized in the following table. All four regimens were well tolerated. Th- ITT PP ITT PP Groups ER ER HR HR A 16/20 (80%) 16/20 (80%) 19/20 (95%) 19/20 (95%) B 22/25 (88%) 22/25 (88%) 24/25 (96%) 24/25 (96%) C 16/20 (80%) 16/19 (84%) 17/20 (85%) 17/19 (90%) D 24/25 (96%) 24/25 (96%) 25/25 (100%) 25/25 (100%) No statistically significant differences in ER and HR were found between the four groups. Only 1 patient in Group C was withdrawn, but not due to adverse events. Conclusions: RBC and azithromycin-based dual or triple therapy with amoxicillin produces very good rate of H. pylori eradication and ulcers healing. Besides insignificant difference in eradication efficacy relating duration of azithromycin treatment (7 vs. 3 days), there was no evident advantage from triple over dual therapy. H. pylori eradication rates over 80% are comparable to rates seen with PPI-based triple therapies.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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