Naslov
Clinical significance of gastric lympho-epithelial lesions

Autori
Katičić, Miroslava ; Dominis, Mara ; Prskalo, Marija ; Džebro, Sonja ; Gašparov, Slavko ; Presečki, Vladimir ; Tićak, Mirjana ; Šabarić, Branka ; Kalenić, Smilja ; Marušić, Marinko ; Plečko, Vanda ; Čolić-Cvrlje, Vesna ; Papa, Branko ; Naumovski-Mihalić, Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut (0017-5749) 43 (1998), suppl. 2 / S.n. - , 1998, A34-A34

Mjesto i datum
,

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; histology; lymphoepithelial lesion (LEL); Sydney classification; MALT lymphoma

Sažetak
Aims: Clinical significance of gastric lymphoepithelial lesion (LEL) is not known. We investigated its prevalence relating to H. pylori infection and eradication. Objective: LEL was diagnosed in 83 (6.2%) (F/M 38/45, mean aged 55.7 god.) of 1362 patients (F/M 576/786, mean aged 54.5) undergone to endoscopy and histology according to Sydney classification. All H. pylori positive patients were treated by one of eradication therapy regimens. Methods: H. pylori infection was initially detected by CLO-Test, histology and culture. A second endoscopy was performed at least 4 weeks after the end of therapy. Eradication was assumed if all the tests (CLO-Test, histology and culture) were negative for H. pylori. Histopathologic routine staining with hematoxylin and eosin, 2% Giemsa, and PAS-Alcian were performed for histopathological diagnosis and detection of H. pylori. Results: 5 patients with LEL and coxisting carcinoma and 2 patients with MALT lymphoma were excluded and 16 patients were lost for follow-up. In all of 44 patients successfully eradicated, LEL disapeared and mucosal inflammatory changes improved in 41 (93.2%) patients. Gastritis score was the same in 3 (6.8%) patients. In 13 patients although H. pylori noneradicated after the first trial of therapy, LEL disappeared in 10 of them, and persisted in 3 patients exhibiting worsening of chronic inflammation and activity. After the second trial of eradication therapy LEL could not be find in 2 patients. During follow-up LEL reappeared in 5 patients earlier H. pylori eradicated and disappeared by itself again in all of them. Conclusion: LEL was diagnosed in 6.2% of patients, always associated with H. pylori infection. After H. pylori eradication LEL disappeared in 64 (98%) of 65 patients. Follow-up of till 4 years didn’t showed no tendency of LEL progression into MALT lymphoma.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA