Pregled bibliografske jedinice broj: 365841
Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides
Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides // Organic Letters, 10 (2008), 12; 2417-2420 doi:10.1021/ol800698t (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 365841 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides
Autori
Majerić Elenkov, Maja ; Tang, Lixia ; Hauer, Bernhard ; Janssen, B. Dick
Izvornik
Organic Letters (1523-7060) 10
(2008), 12;
2417-2420
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cyanate; Epoxides; Oxazolidinones; Halohydrin dehalogenase; Kinetic resolution
Sažetak
Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-0982933-2908 - Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost (Hameršak, Zdenko, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Maja Majerić Elenkov
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
