Naslov
Platelet serotonin concentration in children with attention deficit/hyperactivity disorder with depressive or anxious symptoms.

Autori
Kocijan Hercigonja, Dubravka ; Hercigonja Novković, Vesna ; Nedić, Gordana ; Mustapić, Maja ; Jovančević, Milivoj ; Muck-Šeler, Dorotea ; Pivac, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurologia Croatica, 57 (Suppl. 1) / Hajnšek, Sanja - Zagreb : Denona, 2008, 94-95

Skup
20th Annual meeting of the European Academy of Childhood Disability: "Early Diagnosis Implies Early Intervention", Zagreb, 5-7 June 2008

Mjesto i datum
Zagreb, Hrvatska, Hrvatska

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Platelet serotonin; children; attention deficit/hyperactivity disorder; depressive symptoms; anxious symptoms

Sažetak
Background: Attention-deficit/hyperactivity disorder (ADHD) is a complex and clinically heterogeneous, polygenic psychiatric disorder, highly prevalent in children, frequently associated with different comorbidities. The ethiology of ADHD is thought to be associated with deficits in dopaminergic, noradrenergic and serotonergic systems. Central serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter and neuromodulator in the CNS, involved in the aetiology of psychiatric disorders and pathological behaviours. Central 5-HT regulates cognitive functions, violence, hostility, impulsivity and aggression, and reduced levels of central 5-HT were found in ADHD and depression. Blood platelets share similarities, but also differences, with the central 5-HT neurons. Peripheral 5-HT markers were reported to be decreased, increased or unaffected in ADHD, while platelet 5-HT concentration was altered in depressed, anxious, hostile, impulsive and aggressive subjects. Aim: The aim of the study was to determine platelet 5-HT concentration among boys and girls with ADHD, with symptoms of depression, anxiety and combination of depression and anxiety, and to compare platelet 5-HT concentration with the values in control boys and girls. Methods: ADHD was diagnosed accoriding to DSM-IV criteria (APA 2000), clinical interview, physical examination and Conner’ s Rating Scale for Parents and Teachers ; depressive and anxious symptoms were assessed using State-Trait Anxiety Inventory for Children (STAIC-M), and Beck Depression Inventory Children's Depression Inventory (CDI-M and CDI-Z). Statistics: The results, expressed as means &plusmn ; SD, were evaluated using one-way or two-way analysis of variance (ANOVA) followed by followed by Tukey multiple comparison test. Results: There were no significant (F=0.842 ; df=3, 108 ; p=0.474, one-way ANOVA) differences in platelet 5-HT concentration between boys and girls with ADHD and control boys and girls. No significant effect of diagnosis or gender, and no significant interaction between diagnosis and gender on platelet 5-HT concentration was found (F=0.042 ; df=1, 77 ; p=0.840 ; two-way ANOVA). Age did not differ significantly (F=1.456 ; df=3, 108 ; p=0.231, ANOVA) between boys and girls with ADHD or control boys and girls. Platelet 5-HT concentration was significantly (F=3.42 ; df=4, 55 ; p=0.014, one-way ANOVA) different between children with ADHD who did not show depressive or anxious symptoms, children with ADHD with depressive, anxious and combination of depressive and anxious symptoms. Children with ADHD and depressive symptoms had significantly higher platelet 5-HT concentration than ADHD children without depressive or anxious symptoms (P=0.045 ; Tukey's test), than ADHD children with combination of depressive and anxious symptoms (P=0.008 ; Tukey's test), than children with anxious symptoms (P=0.008 ; Tukey's test) or than control children (P=0.017 ; Tukey's test), respectively. Conclusion: Peripheral indices of 5-HT function are presumed to be associated with particular basic psychopathologic dimensions, but not with diagnostic entities. In line with this hypothesis, children with ADHD had similar platelet 5-HT concentration as control children matched for age. However, ADHD children with depressive symptoms had higher platelet 5-HT concentration than ADHD children with anxious, combination of depressive and anxious symptoms, without depressive or anxious symptoms or control children. Our data confirm the hypothesis that the increased platelet 5-HT concentration in depressive children with ADHD is a trait marker, predictive of depressive symptoms in ADHD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA