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Pregled bibliografske jedinice broj: 364413

Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers

Bozdogan, B.; Appelbaum, P. C.; Kelly, L. M.; Hoellman, D. B.; Tambić Andrašević, Arjana; Drukalska, L.; Hryniewicz, W.; Hupkova, H.; Jacobs, M. R.; Kolman, J. et al.
Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers // Clinical Microbiology and Infection, 9 (2003), 7; 653-661 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 364413 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers

Autori
Bozdogan, B. ; Appelbaum, P. C. ; Kelly, L. M. ; Hoellman, D. B. ; Tambić Andrašević, Arjana ; Drukalska, L. ; Hryniewicz, W. ; Hupkova, H. ; Jacobs, M. R. ; Kolman, J. ; Konkoly-Thege, M. ; Miciuleviciene, J. ; Pana, M. ; Setchanova, L. ; Trupl, J. ; Urbaskova, P.

Izvornik
Clinical Microbiology and Infection (1198-743X) 9 (2003), 7; 653-661

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Central Europe; Eastern Europe; Streptococcus pneumoniae; telithromycin; drug resistance

Sažetak
Objective: To test the activity of telithromycin against 1034 Streptococcus pneumoniae isolates from pediatric patients in ten centers from ten central and eastern European countries during 2000-2001, and to compare it with the activities of erythromycin A, azithromycin, clarithromycin, clindamycin, and quinupristin-dalfopristin. Methods: The minimum inhibitory concentrations (MICs) of telithromycin, erythromycin A, azithromycin, clarithromycin, clindamycin, levofloxacin, quinupristin-dalfopristin and penicillin G were tested by the agar dilution method with incubation in air, and mechanisms of resistance to macrolides and quinolones were investigated. Results: Strains were isolated from sputum, tracheal aspirates, ear, eye, blood, and cerebrospinal fluid. Among S. pneumoniae strains tested, 36% had raised penicillin G MICs (>/= 0.12 mg/L). Susceptibilities were as follows: telithromycin, quinupristin-dalfopristin and levofloxacin, >/= 99% ; clindamycin, 83% ; and erythromycin A, azithromycin and clarithromycin, 78%. Of 230 (22.3%) erythromycin A-resistant S. pneumoniae strains, 176 (79.6%) had erm(B), 38 (16.1%) had mef(A), and 10 (4.3%) had mutations in 23S ribosomal RNA or in ribosomal protein L4. The rates of drug-resistant S. pneumoniae are high in all centers except Kaunas, Riga, and Prague. Conclusion: Telithromycin had low MICs against all strains, irrespective of macrolide, azalide or clindamycin resistance. Ribosomal methylation was the most prevalent resistance mechanism among all resistant strains, except in Sofia, where the prevalence of the efflux mechanism was higher.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Profili:

Avatar Url Arjana Tambić-Andrašević (autor)

www3.interscience.wiley.com

Citiraj ovu publikaciju:

Bozdogan, B.; Appelbaum, P. C.; Kelly, L. M.; Hoellman, D. B.; Tambić Andrašević, Arjana; Drukalska, L.; Hryniewicz, W.; Hupkova, H.; Jacobs, M. R.; Kolman, J. et al.
Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers // Clinical Microbiology and Infection, 9 (2003), 7; 653-661 (međunarodna recenzija, članak, znanstveni)
Bozdogan, B., Appelbaum, P., Kelly, L., Hoellman, D., Tambić Andrašević, A., Drukalska, L., Hryniewicz, W., Hupkova, H., Jacobs, M. & Kolman, J. (2003) Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers. Clinical Microbiology and Infection, 9 (7), 653-661.
@article{article, author = {Bozdogan, B. and Appelbaum, P. C. and Kelly, L. M. and Hoellman, D. B. and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana and Drukalska, L. and Hryniewicz, W. and Hupkova, H. and Jacobs, M. R. and Kolman, J. and Konkoly-Thege, M. and Miciuleviciene, J. and Pana, M. and Setchanova, L. and Trupl, J. and Urbaskova, P.}, year = {2003}, pages = {653-661}, keywords = {Central Europe, Eastern Europe, Streptococcus pneumoniae, telithromycin, drug resistance}, journal = {Clinical Microbiology and Infection}, volume = {9}, number = {7}, issn = {1198-743X}, title = {Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers}, keyword = {Central Europe, Eastern Europe, Streptococcus pneumoniae, telithromycin, drug resistance} }
@article{article, author = {Bozdogan, B. and Appelbaum, P. C. and Kelly, L. M. and Hoellman, D. B. and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana and Drukalska, L. and Hryniewicz, W. and Hupkova, H. and Jacobs, M. R. and Kolman, J. and Konkoly-Thege, M. and Miciuleviciene, J. and Pana, M. and Setchanova, L. and Trupl, J. and Urbaskova, P.}, year = {2003}, pages = {653-661}, keywords = {Central Europe, Eastern Europe, Streptococcus pneumoniae, telithromycin, drug resistance}, journal = {Clinical Microbiology and Infection}, volume = {9}, number = {7}, issn = {1198-743X}, title = {Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers}, keyword = {Central Europe, Eastern Europe, Streptococcus pneumoniae, telithromycin, drug resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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