Naslov
Susceptibility to Telithromycin in 1, 011 Streptococcus pyogenes Isolates from 10 Central and Eastern European Countries

Autori
Nagai, K. ; Appelbaum, P. C. ; Davies, T. A. ; Kelly, L. M. ; Hoellman, D. B. ; Tambić Andrašević, Arjana ; Drukalska, L. ; Hryniewicz, W. ; Jacobs, M. R. ; Kolman, J. ; Miciuleviciene, J. ; Pana, M. ; Setchanova, L. ; Thege, M. K. ; Hupkova, H. ; Truplm J. ; Urbaskova, P.

Izvornik
Antimicrobial Agents and Chemotherapy (0066-4804) 46 (2002), 2; 546-549

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Group-a streptococci; Beta-hemolytic streptococci; Macrolide-resistance; Erythromycin resistance; Genes; Pneumococci; Mechanisms; Phenotypes; Ketolide; Strains

Sažetak
Among 1, 011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC(50)s) and the MIC(90)s were as follows: for telithromycin, 0.03 and 0.06 microg/ml, respectively ; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 microg/ml, respectively ; and for clindamycin, 0.125 and 0.125 microg/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 microg/ml, telithromycin was active against 98.5% of the strains tested.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA