Naslov
Association analysis of G-2548A and A19G polimorphysms in the human leptin gene with obesity

Autori
Tomas, Željka ; Smolej Narančić, Nina ; Barbalić, Maja ; Zajc, Matea ; Škarić-Jurić, Tatjana ; Rudan, Pavao ; Campbell, H. ; Wright, Alan F.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the European Human Genetics Conference 2008 ; u: European Journal of Human Genetics. Supplement 16 (2008) (S) / - : Nature publishing group, 2008, S381-S381

Skup
European Human Genetics Conference 2008

Mjesto i datum
Barcelona, Španjolska, 31.05.2008. - 03.06.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
leptin; polimorphysm; isolated populations

Sažetak
Leptin is a protein hormone which plays an important role in the regulation of body adiposity, lipid metabolism and reproductive function. It is primarily secreted by the adipocytes and its concentration in the blood is proportional to the amount of body fat. Many leptin gene polymorphisms have been found, but their association with obesity is still controversial. We tested the polymorphisms G-2548A in promoter region and A19G in intron 1 of leptin gene for association with leptin concentration in the blood and obesity. A population-based association study was conducted in the population isolate of the Eastern Adriatic island of Vis, Croatia. Three hundred and twenty randomly selected subjects from the Vis population were genotyped. Obesity was defined as BMI≥ 30 kg/m2. The results revealed significant association of G-2548A variant and leptin concentration in a codominant pattern (p=0.026). The ancestral G allele which displays as a minor allele in the Vis population (frequency of 0.44) was associated with higher leptin levels. The leptin concentration was significantly higher in the obese (60.1 ng/ml, N=244), than in the non-obese group (20.7 ng/ml, N=76) and it was more than three times higher in women (44.0 ng/ml) compared to men. However, no association of G-2548A and A19G polymorphisms with obesity was found (with leptin concentration, sex and age as covariates). The results indicate that the studied polymorphisms are not relevant markers for common obesity in this isolated population, but were found to influence the leptin concentration which is an obesity-related phenotype.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA