Naslov
Re: Burkus J. K., Transfeldt E. E., Kitchel S. H., et al. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine 2002 ; 27:2396-408.

Autori
Smoljanović, Tomislav ; Pećina, Marko

Izvornik
Spine (0362-2436) 33 (2008), 2; 224-225

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, stručni

Ključne riječi
Bone morphogenetic protein; unreported vertebral bone resorption

Sažetak
The report after the end of pivotal phase of the mentioned research in which 18% patients (14 of 79) in the rhBMP-2 group had transient localized areas of bone remodeling drew our attention. A more careful examination of the pilot phase report, i.e., Figure 10, showed unreported resorption of vertebral bodies adjacent to the allograft 6 months following surgery (Figure 1). Possible effects of not revealing the unanticipated adverse findings are numerous. Fortunately, a clinical significance in this case seems to be negligible since, by the words of the authors, all 18% of patients with increased bone resorption healed 24 months after the surgery.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA