Naslov
High macrolide resistance of nasopharyngeal isolates of Streptococcus pneumoniae in children from Zagreb region

Autori
Vraneš, Jasmina ; Senji, Peter ; Anušić, Maja ; Jarža-Davila, Neda ; Bedenić, Branka ; Knežević, Jasna ; Marijan, Tatjana ; Leskovar, Vladimira

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
26th Annual Meeting of the European Society for Paediatric Infectious Diseases

Mjesto i datum
Graz, Austrija, 13.05.2008. - 17.05.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Streptococcus pneumoniae; resistance; macrolide

Sažetak
Background and aims: It is well known that monitoring of antimicrobial resistance of nasopharyngeal strains of Streptococcus pneumoniae is an excellent approach for prediction of resistance in clinical isolates. The aim of this study was to determine the susceptibility of nasopharyngeal isolates of S. pneumoniae to antimicrobial agents. Methods: Nasopharyngeal swabs were collected from 634 children aged 1-15 (the median age was 3 years) in two-month period (October-November, 2007). After cultivation and identification of S. pneumoniae, 93 strains were tested by a broth microdilution method, and minimal inhibitory concentrations (MICs) was determined for penicillin G, amoxicillin, ceftriaxone, cefuroxime, meropenem, erythromycin, azithromycin and clarithromycin. Results: The resistance to penicillin was determined in 31 (33.3%) strains with a 12.9% of highly resistant S. pneumoniae isolates. The resistance to other beta-lactams was lower with less than 10% of non-susceptibility to ceftriaxone and only 6.4% isolates intermediately resistant to amoxicillin. Macrolides showed decreased activity against tested strains, with resistance being 38.7%, 36.6% and 33.3% for erythromycin, azithromycin and clarithromycin, respectively. MIC90 of azithromycin and clarithromycin was 512 mg/L, while MIC90 of erythromycin was 1024 mg/L. Conclusions: Amoxicillin showed the best in vitro activity among tested antibiotics, and thus might be considered as a drug of choice for the therapy of infections of possible pneumococcal etiology in children. The high macrolide resistance observed compromise clinical utility of these antibiotics and might be explained by extensive out-patient use of azithromycin in Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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