Naslov
Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection

Autori
Mlinarić-Galinović, Gordana ; Chonmaitree, Tasnee ; Cane, Patricia A. ; Pringle, Craig R. ; Ogra, Pearay L.

Izvornik
Journal of medical virology (0146-6615) 42 (1994), 4; 380-384

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
RSV subgroups; acute respiratory viral infection; monoclonal antibodies; G-gene restriction pattern

Sažetak
The epidemiological characteristics and relationship between respiratory syncytial virus (RSV) subgroup and virulence during an outbreak of RSV infection occurring in Southeast Texas in the winter season 1991/92 are described. Fiftytwo infants and children were diagnosed with RSV infection by rapid viral antigen detection and/or viral isolation. Subgrouping of the isolates was carried out using 11-monoclonal antibodies. Ten isolates were found to be subgroup B, and 8 isolates were subgroup A. The subgroup B strains showed 3 different patterns of reaction with monoclonal antibodies ; one of these subgroups was examined further by restriction analysis of parts of its nucleocapsid and attachment protein genes. Both subtypes A and B circulated simultaneously in the same territory. The more frequent occurrence of the B subgroup and the diversity of its simultaneously circulated RSV strains have made this outbreak unusual.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA