Naslov
Soluble adhesion molecules in hypertension are reflective of profound pathogenesis disturbance.
(Soluble adhesion molecules in hyperthension are reflective of profound pathogenesis disturbance)

Autori
Majnarić-Trtica, LJ ; Ebling, Z ; Martinis, M ; Vitale, B

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Atherosclerosis / - , 2007, 409-409

Skup
Atherosclerosis

Mjesto i datum
Oslo, Norveška, 2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
soluble adhesion moleculs; hyperthension pathogenesis
(soluble adhesion moleculs; hypertension; pathogenesis.)

Sažetak
Mediated by upregulated adhesion molecules on endothelial cells, mononuclear leukocytes participate in the formation of atherosclerotic plaques. Hypertensio is a major cardiovascular risk faktor. In this study, levels of soluble adhesion molecules E-selection and ICAM-1 Werw determined in a group of 79 subject with uncomplicated hypertensio and free of diabetes mellitus, aged 50-65 years, and 35 nonhypertensive subjects as the controlos. The relationships werw also assessed with parameters indicating: 1. risk factor (BMI, fasting glucose, total cholesterol and triglycerides), 2. markers of inflammation (total leukocyte count, C - reactive protein and red blood cell sedimentation rate) and 3. markers of renal dysfunction (24 h urine albumin, total protein in urine and creatinine clearance). Results showed that soluble adhesion molecules are not raised in hypertensive patients without manifest cardiovascular diseases, as comparedto the nonhypertensive controlos. Parameters selected in multiple regression analyses, performed for soluble E-selectin, were: BMI, triglicerides, total leukocytes count and 24 urine albumin – representing features of the insulinresistance syndrome. Parameters selected to independently correlate withthe plasma levels of soluble P-selection: red blood cell sedimentation rate, total leukocyte count and total cholesterol – indicate disturbed hemortheology. Soluble ICAM-1 showed correlations with C-reactive protein and markers of renal dysfunction (total protein in urine and reverse correlation with creatinine clearance), but only in univariate correlation with creatinine clearance), but only in univariate correlations. All this leads to the conclusion that the conclusion that the raised levels of soluble adhesion molecules may in hypertensive patients not be merely the consequence of high blood pressure, but rather reflect common underlying pathogenetic disturbances.

Izvorni jezik
Engleski

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