Pregled bibliografske jedinice broj: 357628
Selenium status and glutathione peroxidase activity in arsenic exposed subjects in eastern Croatia
Selenium status and glutathione peroxidase activity in arsenic exposed subjects in eastern Croatia // Book of abstracts of the 2nd International Congress Arsenic in the environment (As 2008 ): Arsenic from nature to humans
Valencia, 2008. str. S469-S469 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 357628 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Selenium status and glutathione peroxidase activity in arsenic exposed subjects in eastern Croatia
Autori
Ćavar, Suzana ; Klapec, Tomislav ; Jurasović, Jasna ; Milić, Marija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of abstracts of the 2nd International Congress Arsenic in the environment (As 2008 ): Arsenic from nature to humans
/ - Valencia, 2008, S469-S469
Skup
2nd International Congress Arsenic in the environment : Arsenic from nature to humans (2 : 2008)
Mjesto i datum
Valencia, Španjolska, 21.05.2008. - 23.05.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
arsenic; selenium; glutathione peroxidase
Sažetak
Blood selenium (BSe), creatinine-adjusted urinary Se (USe) and arsenic (UAs), as well as glutathione peroxidase activity (GPx), were determined in adult subjects from two Croatian areas with disparate levels of As in drinking water (Osijek: 37.9 mug/L and Andrijaševci: 612 mug/L). BSe was determined using GFAAS, USe and UAs were measured with HGAAS and GPx activities were analyzed using a commercial kit (Ransel, Randox Laboratories, UK). Creatinine was determined in all urine samples with automated chemistry analyser using a colorimetric Jaffe rate method. The median BSe levels in healthy adults were 95.1 mug/L (N= 25, range 66.0-117.2 mug/L) in Osijek and 74.3 mug/L (N= 38, range 48.6-113.7 mug/L) in Andrijaševci (p<0.01), respectively. The median GPx activity was also significantly lower in subjects from the high-As location (35.9 vs 45.8 U/gHb ; p<0.01). While USe and UAs were positively correlated in the control group (Spearman rank r=0.41 ; p=0.067), a nonsignificant negative correlation was observed in the high exposure subjects (r=-0.14 ; p=0.417). These preliminary findings are in agreement with previously observed effect of high As intake on increased biliary Se elimination which could contribute to As-induced oxidative stress.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Prehrambena tehnologija
POVEZANOST RADA
Projekti:
006-0061117-1238 - Bioaktivne prirodne tvari: izolacija, karakterizacija i biološki učinci (Vladimir-Knežević, Sanda, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prehrambeno-tehnološki fakultet, Osijek,
Klinički bolnički centar Osijek
