Naslov
Eradication of Helicobacter pylori in children:prospective randomized study of two PPI-base triple therapies

Autori
Kolaček, Sanja ; Percl, Mirjana ; Lukić-Grlić, Amarela ; Dasović, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Gut / - , 2000, 286-286

Skup
8th United European Gastroenterology Week

Mjesto i datum
Bruxelles, Belgija, 2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; therapy; children

Sažetak
Background:There is no defined treatment for eradication of H.pylori in children. Moreover, proton pump inhibitors (PPI) are not available for regular use in paediatric patients, and therefore the experience is limited. Aims:The aim of this study was to evaluate the efficacy of two PPI-based tripple therapy regimens in symptomatic H.pylori positve (by culture, hisotlogy and C13-UBT) children. Methods:37 consecutive H.pylori positive patients were randomly assigned to one of two tripple therapy groups. Group A (17 patients, mean age 13y) received azithromycin for 5 days, pantoprazol for 10 days and metronidazol for 10 days. Group B (20patients, mean age 12 y) received pantoprazol, amoxicillin and metronidazol for 10 days. The efficacy of treatment was assessed by C13-UBT 4 weeks after completion of therapy, while susceptibility was determined by E-test. Resultus:Eradication has been achieved in 12/17 patients in group A(70%) and in 19/20 patients in group B (95%)(p<0.01). There were no side-effects of either treatment regimen. All H.pylori strains were sensitive to amoxicillin, while primary resistance to both azithromycin and metronidazol was determined in 5/19 isolates (26%). Conclusion: The efficacy of eradication was significantly better in group B receiving amoxicillin, metronidazol and pantoprazol compared to paediatric patients receiving azithromycin, metronidazol and patroprazol.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA