Naslov
Lead interference in zinc metabolism and the lead and zinc interaction in humans as a possible explanation of apparent individual susceptibility to lead

Autori
Telišman, Spomenka ; Pizent, Alica ; Prpić-Majić, Danica

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Heavy Metals in the Environment / Allan RJ, Nriagu JO - Edinburgh : CEP Consultants, 1993, 404-407

ISBN
0 905941 51 9

Skup
9th International Conference on Heavy Metals in the Environment

Mjesto i datum
Toronto, Kanada, 12.09.1993. - 16.09.1993

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
blood lead; serum zinc; seminal zinc

Sažetak
Serum zinc (ZnS), seminal fluid zinc (ZnF), blood lead (PbB), and activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) were measured in 152 adult male subjects, not occupationally exposed to zinc: 101 lead workers with long-term slight to moderate occupational lead exposure and 51 control subjects with no occupational lead exposure. Significant correlations were found between a decrease of ZnS with respect to an increase of PbB (r=-0.135, P<0.05) and a decrease of ALAD (r=0.237, P<0.002), between a decrease of ZnF with respect to PbB (r=-0.245, P<0.001) and ALAD (r=0.262, P<0.001), and between ZnS and ZnF (r=0.255, P<0.001). The results indicate possible lead interference in zinc metabolism resulting in relative zinc deficiency, and thus lead-zinc interaction which can influence ALAD as well as some other lead-related effects. This might explain a large part of the interindividual differences in response to the same PbB level, i.e. apparent individual susceptibility to lead, which was ascribed to genetic factors.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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