Naslov
Antibiotic resistance of Helicobacter pylori in croatian children

Autori
Kolaček, Sanja ; Percl, M ; Mišak, Zrinjka ; Jadrešin, Oleg ; Lukić-Grlić, Amarela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Gut / - , 2003, 201-201

Skup
11th United European Gastroenterology Week

Mjesto i datum
Madrid, Španjolska, 2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; antibiotics; resistance; children

Sažetak
The primary antibiotic resistance of Helicobacter pylori (HP) greatly affects its eradication by common treatment regimens (two antibiotics and proton pump inhibitor). Most commonly used antibiotics are amoxicillin, metronidazole, clarythromycin, and azitromycin. Data concerning primary antibiotic HP resistance in children are rare, especially concerning azitromycin. First, to evaluate the prevalence of primary resistance of HP to amoyicillin, metronidazole and azytromycin in pediatric patients. Second, to assess the evolution of resistance with time. From 1999 to 2002, HP infection was identified in 52 children (34 girls, 18 boys, mean age 13 years) by culturing specimens taken at the upper endoscopy. All patients were treated with two antibiotics and with pantoprazole (1-2 mg/kg in two divided dosis)during 10 danys. Susceptibility to antibiotics was tested by agar dilution techniyue or E test. Minimal inhibitory concetrations (ug/L) were for metronidazole 4, azytromycin 4 and amoxicillin 0, 5. Patients were divided into two groups: those endoscopied from 1999 to 2000 (N=25, Group A) and those diagnosed from 2000 to 2002 (N=27, Group B): Primary resistance of HP to amoxicillin was not detected in any patient. 13 patients (25%) were resistant to metronidazole, and 11 patients (21%) were resistant to azitromycin. 2. Double resistance was found in 4 patients (7.7%. 3. In group A, HP resistance to metronidazol and to azitromycin was 32% and 24%, respectively, which was not significatnly different from group B (18% and 18%) (p>0.05). There was no significant difference between sexes. In our paediatric patients, the primary resistance of HP to metronidazole and to azithromycin was exceptionally high (25% and 12%). There were no significant changes in antibiotic resistance during the observed period.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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