Naslov
Continuous Subcutaneous Insulin Infusion (CSII)

Autori
Prašek, M ; Božek, T ; Metelko, Ž

Izvornik
Diabetologia Croatica (0351-0042) 32 (2003), 3; 111-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
continuous subcutaneous insulin infusion (CSII); type 1 diabetes mellitus; absorption variability; insulin analog; hypoglycemia; ketoacidosis; blood glucose self-monitoring

Sažetak
Intensive diabetes management can be achieved in children, adolescents and adults either with the use of continuous subcutaneous insulin infusion or with multiple daily injections. The goals of intensive diabetes management established by the Diabetes Control and Complications Trial are to achieve near normal glycemia, to avoid short-term crises such as hypoglycemia requiring third part assistance or intervention, to minimize longterm complications, and to improve the quality and length of life in persons suffering from diabetes. The importance of tight metabolic control in patients with diabetes was also demonstrated by the results of United Kingdom Prospective Diabetes Study, and emphasized in the Saint Vincent Declaration. Disadvantages of multiple daily injections are the need for patients to take three or even more injections per day by syringe or pen, resulting in poor compliance, and to use modified insulins, intermediate or long-acting insulins (NPH, Lente, Ultra-lente) that must be injected to reach basal concentration of insulin to keep blood glucose within normal limits between meals. It has been clearly shown that absorption of modified insulins vary from 19% to 55% in the same individual, which could be the reason for blood glucose variability. Conversely, the absorption of soluble, short-acting insulins that are used in continuous subcutaneous insulin infusion varies by less than 3% daily. As the result of continuous subcutaneous insulin infusion – insulin pump therapy and use of a continuous glucose sensor, achievement of the main goals in diabetes treatment could rather become a matter of fact. During recent years continuous subcutaneous insulin infusion has reached widespread recognition, as it has become the mode of intensive diabetes treatment for more than 200 000 diabetic patients worldwide.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA