Naslov
Pyrimidine degradation in E. coli: I. Effect of dihydrouracil and barbituric acid on growth of whole bacteria

Autori
Šimaga, Šumski ; Kos, Erika

Izvornik
Journal of international research communication (0300-5569) 1 (1973), 10; 9-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
E.coli ; pyrimidine catabolism ; dihydrouracil ; barbituric acid

Sažetak
In media suboptimally supplied with a nitrogen source, bacteria E.coli catabolise pyrimidines, thymine and uracil, to ureido-CO2. The aim of investigations reported here was to establish which of the two known degradation mechanisms - oxidative via barbituric acids or reductive via dihydropyrimidines, might be operating in E. coli K12S. By combining the growth- and biochemical experimenths, it was shown that clue intermediates of above pathways do not affect the bacterial growth and are not catabolised to ureido-CO2. Since urea only was identified as a catabolite but bacteria showed no urease activity, it was concluded that pyrimidine degradation in E.coli K12S starved for nitrogen source, proceeds by different mechanism.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA