Naslov
Normal variation of bronchial reactivity in nonasthmatics is associated with the level of mite-specific IgE

Autori
Nogalo, Boro ; Mirić, Mirjana ; Maloča, Ivana ; Turkalj, Mirjana ; Plavec, Davor

Izvornik
Journal of Asthma (0277-0903) 45 (2008), 4; 273-277

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bronchial reactivity; mite-specific IgE; nonasthmatics

Sažetak
Objective: To investigate association between non-specific bronchial reactivity (NBR) and level of mite specific IgE amongst mite-sensitized non-asthmatic subjects. Methods: Subjects attending occupational check-up were assessed for: respiratory symptoms, atopic status (skin prick testing [SPT], total and specific IgE), spirometry and NBR. Individuals without history of respiratory disease (N = 234) were included into analysis. Results: All subjects had normal spirometry and 99% had normal NBR while 41.8% had detectable specific IgE to mites. Lung function parameters and NBR were significantly lower in mite sensitized subjects. Multiple regression analysis controlling for age, gender, smoking, family history, SPT, IgE, and lung function showed that NBR was significantly associated only with mite specific IgE level (beta = 0.26 ; 95% CI, 0.05-0.47 ; p = 0.018). Conclusion: Even in subjects without allergic symptoms, IgE-mediated sensitization does not appear to be all or nothing phenomenon influencing the normal variability of underlying airway reactivity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA