Pregled bibliografske jedinice broj: 353218
Biological Agents targeting Interleukin-18
Biological Agents targeting Interleukin-18 // Drug News and Perspectives, 20 (2007), 8; 485-494 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 353218 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Biological Agents targeting Interleukin-18
Autori
Jelušić, Marija ; Lukić, Ivan Krešimir ; Batinić, Drago
Izvornik
Drug News and Perspectives (0214-0934) 20
(2007), 8;
485-494
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
Interleukin-18; diseases
Sažetak
IL-18, initially cloned as an interferon (IFN)-γ inducing factor, is an important regulator of both innate and acquired immune responses. It is up-regulated in several human autoimmune and inflammatory diseases, and, therefore, might represent a novel therapeutic target. This review highlights the biology of IL-18, its central role in inflammation and immune response, and the various therapeutic strategies of IL-18 blockade, including recombinant human IL-18BP, anti-IL-18 monoclonal antibodies, soluble heterodimeric IL-18R, and the inhibition of IL-18 secretion via inhibition of caspase-1 or antagonism of the P2X-7 receptor.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-0000000-0125 - Fetalna kardiološka služba u zaštiti perinatalnog mortaliteta i morbiditeta (Malčić, Ivan, MZOS ) ( CroRIS)
214-1081347-0355 - Uloga PI3K/Akt i MAPK u regulaciji kemorezistencije leukemijskih stanica (Batinić, Drago, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
