Pregled bibliografske jedinice broj: 35234
Population genetic studies of HLA-G - allele frequencies and linkage disequilibrium with HLA-A1
Population genetic studies of HLA-G - allele frequencies and linkage disequilibrium with HLA-A1 // Journal of reproductive immunology, 32 (1996), 2; 111-123 doi:10.1016/s0165-0378(96)01000-5 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 35234 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Population genetic studies of HLA-G - allele
frequencies and linkage disequilibrium with HLA-A1
Autori
Ober, C. ; Rosinsky, B. ; Grimsley, C. ; van der Ven, Katrin ; Robertson, A. ; Runge, A.
Izvornik
Journal of reproductive immunology (0165-0378) 32
(1996), 2;
111-123
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HLA-G ; allele frequencies ; HLA-A1
Sažetak
HLA-G is a class I gene that is expressed in the extravillous cytotrophoblast. Although the function of this gene is still unknown, its expression at the maternal-fetal interface suggests that HLA-G may play a key role in the induction of tolerance during pregnancy. Preliminary to our studies of the effects of HLA-G polymorphisms on pregnancy outcome, we have defined HLA-G alleles in the Hutterites. We report here the presence of nine HLA-G alleles that differ with respect to nucleotide sequences, including four groups of alleles that differ with respect to amino acid sequences, and striking linkage disequilibrium between HLA-G and HLA-A alleles. The levels and sites of polymorphism in HLA-G suggest that this gene had a unique evolutionary history and may perform nonclassical functions at the maternal-fetal interface.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
