Naslov
The Effect of Repeated Daily Measurements on Paw Withdrawal Latencies in Hargreaves Test

Autori
Kocevski, Dragana ; Tvrdeić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of The Second Croatian Congress of Neuroscience ; u Neurologia Croatica 57 (2007 ) (S) / Petravić, D. - Zagreb, 2007, 60-61

Skup
Croatian Congress of Neuroscience (2 ; 2007)

Mjesto i datum
Zagreb, Hrvatska, 18.05.2007. - 19.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
pain; rats; training; Hargreaves test

Sažetak
The hypothesis that repeated measurements during 4 subsequent days affect withdrawal latencies in Hargreaves test was investigated. Paw withdrawal latencies to radiant heat were determined in the control, tramadol or saline group of male Wistar rats. The control group (N=10) had no treatment. Tramadol group (N=7) and saline group (N=7) received one daily intraperitoneal injection of tramadol (15 mg/kg) or saline (0.9% NaCl), respectively. A significant decline in withdrawal latencies was observed in the control group on the day 2 to day 4, when compared to day 1 (p<0.05 Bon- ferroni test). In the saline and tramadol groups, latencies remained stable from day 1 to day 4. During the entire testing period withdrawal latencies were 27– 50% longer in tramadol group (p<0.05 ANOVA) compared with the saline group. When compared to the control group, the effect of tramadol, was noted from the second to forth day (p<0.01 Bonferroni test), but not on the first day. Finally, a tendency to decrement in withdrawal latencies existed on day 1 in the saline group compared with control group, but this difference does not reach significance. We conclude that one day of training affect withdrawal latencies in the Hargreaves test.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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